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The excessive complexity of both machine architectures and applications have made it difficult for compilers to statically model and predict application behavior. This observation motivates the recent interest in performance tuning using empirical techniques. We present a new embedded scripting language, POET (parameterized optimization for empirical(More)
Basic Liner algebra subprograms (BLAS) is a fundamental library in scientific computing. In this paper, we present a template-based optimization framework, AUGEM, which can automatically generate fully optimized assembly code for several dense linear algebra (DLA) kernels, such as GEMM, GEMV, AXPY and DOT, on varying multi-core CPUs without requiring any(More)
Previous studies demonstrated that circulating dendritic cells (DCs) in myeloma patients were functionally abnormal. However, the phenotype and function of patients' monocyte-derived DCs (MoDCs), which are commonly used for immunotherapy, were poorly defined. This study was undertaken to examine the quality of MoDCs from myeloma patients compared with cells(More)
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases(More)
Multiple myeloma remains an incurable disease. One of the major problems is that myeloma cells develop drug resistance on interaction with bone marrow stromal cells. In this study, we examined the effects of macrophages (Mvarphis), a type of stromal cells, on myeloma cell survival and response to chemotherapy. We showed that Mvarphi, in particular(More)
Dendritic cells (DCs) from patients with cancer are functionally defective, but the molecular mechanisms underlying these defects are poorly understood. In this study, we used the murine 5TGM1 myeloma model to examine the effects and mechanisms of tumor-derived factors on the differentiation and function of DCs. Myeloma cells or tumor culture conditioning(More)
OBJECTIVE To establish risk factors for the occurrence of post-traumatic endophthalmitis, to observe the efficacy of prophylaxis, and to describe the clinical features of post-traumatic endophthalmitis. DESIGN Partially prospective consecutive case-control study. PARTICIPANTS A total of 250 consecutive patients admitted to a single ophthalmic hospital(More)
PURPOSE To determine the efficacy and safety of topical autologous serum as a treatment of dry eye patients. METHODS A 2-month, prospective, single-masked, placebo-controlled study was conducted in patients with bilateral severe dry eye. One eye was randomized to receive the patient's own serum as a tear substitute, and the fellow eye received unpreserved(More)
We present POET, a scripting language designed for applying advanced program transformations to code in arbitrary programming languages as well as building adhoc translators between these languages. We have used POET to support a large number of compiler optimizations, including loop interchange, parallelization, blocking, fusion/fission, strength(More)
BACKGROUND Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-Hodgkin's lymphoma. To the authors' knowledge, little is known regarding its incidence patterns and associated factors. The purpose of the current study was to examine the incidence of MCL over a period of 13 years and to identify the factors associated with the incidence patterns. (More)