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CONTEXT Endometriosis is an estrogen-dependent disease. Steroidogenic factor-1 (SF-1), a transcriptional factor essential for activation of multiple steroidogenic genes for estrogen biosynthesis, is undetectable in normal endometrial stromal cells and aberrantly expressed in endometriotic stromal cells. OBJECTIVE The objective of the study was to unravel(More)
Super-Resolution is the problem of generating one or a set of high-resolution images from one or a sequence of low-resolution frames. Most methods have been proposed for super-resolution based on multiple low resolution images of the same scene, which is called multiple-frame super-resolution. Only a few approaches produce a high-resolution image from a(More)
The genetic mechanism underlying panicle number per plant (PN), spikelet number per panicle (SNP) and its related traits in rice was analysed using 292 F13 RILs from the cross of Lemont/Teqing and a complete linkage map with 272 molecular markers. The RILs showed tremendous transgressive segregation for all traits studied. The weak negative correlation(More)
The capsaicin receptor, also known as 'transient receptor potential vanilloid receptor subtype 1' (TRPV1, VR1), is an ion channel subunit expressed in primary afferent nociceptors, which plays a critical role in pain transduction and thermal hyperalgesia. Increases in nociceptor TRPV1 mRNA and protein are associated with tissue injury-inflammation. As(More)
BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique used to alter cortex excitability that has been proposed as an efficient method for treating brain hyperexcitability or hypoexcitability disorders. The aim of this study was to investigate whether high-frequency rTMS could have any beneficial effects in restless legs(More)
OBJECTIVE To assess Doppler ultrasonography by comparing its detection of sacroiliitis with detection of enthesitis in patients with ankylosing spondylitis (AS). METHODS One hundred sixty-one patients with AS (according to modified New York criteria or Spondyloarthritis International Society classification criteria for axial spondyloarthritis) underwent(More)
Steroid receptors in the stromal cells of endometrium and its disease counterpart tissue endometriosis play critical physiologic roles. We found that mRNA and protein levels of estrogen receptor 2 (ESR2) were strikingly higher, whereas levels of estrogen receptor 1 (ESR1), total progesterone receptor (PGR), and progesterone receptor B (PGR B) were(More)
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine(More)
Heparan sulfate (HS) proteoglycans (HSPGs) bind to multiple growth factors/morphogens and regulate their signaling. 6-O-sulfation (6S) of glucosamine within HS chains is critical for many of these ligand interactions. Sulf-1 and Sulf-2, which are extracellular neutral-pH sulfatases, provide a novel post-synthetic mechanism for regulation of HSPG function by(More)
CONTEXT Uterine leiomyomas are smooth muscle cell tumors that cause irregular uterine bleeding and pregnancy loss in many reproductive-age women. Progesterone stimulates their growth, whereas treatment with progesterone receptor (PR) antagonists or selective progesterone receptor modulators shrinks these tumors. Molecular mechanisms underlying these(More)