Qing-Xuan Zeng

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Twenty-three new berberine (BBR) analogues defined on substituents of ring D were synthesized and evaluated for their activity for suppression of tumor necrosis factor (TNF)-α-induced nuclear factor (NF)-κB activation. Structure-activity relationship (SAR) analysis indicated that suitable tertiary/quaternary carbon substitutions at the 9-position or rigid(More)
During the preparation of amino phosphoric chelating fiber, polypropylene grafted styrene, acetyl, amine series and amino phosphonic acid chelating fibers were certified by infrared spectrum, and the functionalization degree of raw fibers was studied. By the semi-qualitative method of infrared spectrum, the adsorption performance of indium and copper on(More)
The hygroscopic properties of supersaturated aerosols as a function of relative humidity (RH) can be determined on the molecular level by the solutes with varied structures, as well as the solvent in the state of solvated water or free water. Although the former has been investigated by FTIR and Raman spectroscopy, the latter has gone mostly unnoticed. In(More)
Dissipative particle dynamics (DPD) simulations are performed to study the cooperative self-assembly of coil-rod-coil triblock copolymers and nanoparticles in solution. The results show that, when the nanoparticle concentration exceeds a given value, the ternary systems can form a novel nanocage composed of two-end coil-caps and middle rod-linkers. The(More)
To discover small-molecule cancer immunotherapy candidates through targeting Indoleamine 2,3-dioxygenase 1 (IDO1), twenty-five new berberine (BBR) derivatives defined with substituents on position 3 or 9 were synthesized and examined for repression of IFN-γ-induced IDO1 promoter activities. Structure-activity relationship (SAR) indicated that large volume(More)
Cerebral infarction disease is a severe hypoxic ischemic tissue necrosis in the brain, often leading to long-term functional disability and residual impairments. The Notch signaling pathway plays key roles in proliferation and survival of the stem/progenitor cells of the central and peripheral nervous systems. Notch3 is an important member of the pathway,(More)
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