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In this study, we developed a real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) method to study cytochrome P450 (CYP) mRNA regulation by cytokines in mouse liver. The method combines standard RT-PCR with a fluorogenic probe in which the intensity of fluorescence is proportional to the amount of target template present. We show(More)
Using a spread of PG(3; p) and certain projective two-weight codes, we give a general construction of Hadamard diierence sets in groups H (Z p) 4 , where H is either the Klein 4-group or the cyclic group of order 4, and p is an odd prime. In the case p 3 (mod 4), we use an ovoidal bration of PG(3; p) to construct Hadamard diierence sets, this construction(More)
A set of binary sequences (here binary means the element of the sequence is +1 or -1.) is called a set of periodic complementary binary sequences (PCS) if the sum of the periodic autocorrelation functions of all sequences is a delta function. More precisely, let {al, 0 _< i <_ p -1} be a set of p binary sequences each with N elements. Every element of the a(More)
An explicit construction of a family of binary LDPC codes called LU(3, q), where q is a power of a prime, was recently given. A conjecture was made for the dimensions of these codes when q is odd. The conjecture is proved in this note. The proof involves the geometry of a 4-dimensional symplectic vector space and the action of the symplectic group and its(More)
Group II intron RNPs are mobile genetic elements that attack and invade duplex DNA. In this work, we monitor the invasion reaction in vitro and establish a quantitative kinetic framework for the steps of this complex cascade. We find that target site specificity is achieved after DNA binding, which occurs nonspecifically. RNP searches the bound DNA before(More)
Let (K,+, ∗) be an odd order presemifield with commutative multiplication. We show that the set of nonzero squares of (K, ∗) is a skewHadamard difference set or a Paley type partial difference set in (K,+) according as q is congruent to 3modulo 4 or q is congruent to 1 modulo 4. Applying this result to the Coulter–Matthews presemifield and the Ding–Yuan(More)
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is found with high frequency in many human cancer cells, pharmacological inhibition of CDKs with small molecules has the potential to provide an effective strategy for the treatment of cancer. The 2,4-diamino-5-ketopyrimidines 6(More)