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Towards precise classification of cancers based on robust gene functional expression profiles
Inspired by the insight that genes act as a module to carry out a highly integrated cellular function, this modular approach is demonstrated to be a powerful alternative approach to analyzing high dimension micro array data and is robust to high measurement noise and intrinsic biological variance inherent in microarray data.
Premature myocardial infarction novel susceptibility locus on chromosome 1P34-36 identified by genomewide linkage analysis.
A novel genetic-susceptibility locus is identified for MI and a framework for the ultimate cloning of a gene for the complex disease MI is provided.
Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling
A usable and powerful model-free approach to dissecting high-order dynamic trends of gene-gene interactions is established and can be used to study the complex gene regulations related to the development, aging and progressive pathogenesis of a complex disease where potential dependences between different experiment units might occurs.
Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.
- Shenghan Chen, W. Ondo, Shaoqi Rao, Lin Li, Qiuyun Chen, Qing Wang
- BiologyAmerican journal of human genetics
- 1 May 2004
RLS is established as a highly heritable trait, a novel genetic locus for RLS is identified, and the assumption of an autosomal-dominant mode of inheritance is validated, which will facilitate further cloning and identification of the genes.
A robust hybrid between genetic algorithm and support vector machine for extracting an optimal feature gene subset.
Transcription factor MEF2A mutations in patients with coronary artery disease.
It is suggested that CAD/MI can result from a spectrum of MEF2A transcription dysfunctions ranging from loss-of-function to dominant-negative suppression and that a significant percent of the CAD/ MI population may carry mutations in MEF 2A, although further definition of the prevalence is warranted.
Proteomic approach to coronary atherosclerosis shows ferritin light chain as a significant marker: evidence consistent with iron hypothesis in atherosclerosis.
In situ proteomic evidence is provided consistent with the "iron hypothesis," which proposes an association between excessive iron storage and a high risk of CAD, and suggests that increased expression of the ferritin light chain may contribute to pathogenesis of CAD by modulating oxidation of lipids within the vessel wall through the generation of reactive oxygen species.
Identification of new genes differentially expressed in coronary artery disease by expression profiling.
Large-scale gene expression analysis of approximately 12,000 human genes in nine severely atherosclerotic and six nonatherosclerosis human coronary arteries identified 56 genes whose expression is associated with CAD, and 49 of them may represent new genes linked to CAD.
Genome-Wide Linkage Scan Identifies a Novel Genetic Locus on Chromosome 5p13 for Neonatal Atrial Fibrillation Associated With Sudden Death and Variable Cardiomyopathy
A genetic link between AF and prolonged P-wave duration was identified and a framework for the ultimate cloning of the arAF1 gene is provided, which will increase the understanding of the fundamental molecular mechanisms of atrial fibrillation.
Miscues on the "lack of MEF2A mutations" in coronary artery disease.
T careful analysis of family data suggests that the available clinical data are insufficient to make any conclusions and certainly does not support the author’s conclusion that the 21-bp deletion of MEF2A does not cosegregate with the disease and does not cause CAD.