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Long QT syndrome (LQT) is an inherited disorder that causes sudden death from cardiac arrhythmias, specifically torsade de pointes and ventricular fibrillation. We previously mapped three LQT loci: LQT1 on chromosome 11p15.5, LQT2 on 7q35-36, and LQT3 on 3p21-24. Here we report genetic linkage between LQT3 and polymorphisms within SCN5A, the cardiac sodium(More)
—A new universal estimator of divergence is presented for multidimensional continuous densities based on k-nearest-neighbor (k-NN) distances. Assuming independent and identically distributed (i.i.d.) samples, the new estimator is proved to be asymptotically unbiased and mean-square consistent. In experiments with high-dimensional data, the k-NN approach(More)
The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form the basis of contralateral motor control and sensory input. The motor and sensory projections appeared uncrossed in patients with(More)
Gasterophilus nigricornis (Loew) (Diptera: Oestridae) is one of the most damaging obligate parasites of equids in Kalamaili, Xinjiang, China. The main olfactory organs of this stomach bot fly are paired antennae that bear microscopic sensillar structures. The external morphology of the antennal funiculus and sensilla of male G. nigricornis were studied(More)
—Device-to-Device (D2D) communication was initially proposed in cellular networks as a new paradigm to enhance network performance. The emergence of new applications such as content distribution and location-aware advertisement introduced new use-cases for D2D communications in cellular networks. The initial studies showed that D2D communication has(More)
Fibroblast growth factor 14 (FGF14) belongs to a distinct subclass of FGFs that is expressed in the developing and adult CNS. We disrupted the Fgf14 gene and introduced an Fgf14(N-beta-Gal) allele that abolished Fgf14 expression and generated a fusion protein (FGF14N-beta-gal) containing the first exon of FGF14 and beta-galactosidase. Fgf14-deficient mice(More)
provide open public road safety services and the improve comfort and efficiency of driving. Based on the latest standard draft IEEE 802.11p and IEEE 1609.4, this paper proposes a variable CCH interval (VCI) multichannel medium access control (MAC) scheme, which can dynamically adjust the length ratio between CCH and SCHs. The scheme also introduces a(More)
Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in early childhood. Here we show that the specific AF gene underlying this linkage is NUP155, which encodes a member of the nucleoporins, the components of the nuclear pore complex (NPC). We(More)