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BACKGROUND There is much uncertainty about the effects of early lowering of elevated blood pressure (BP) after acute intracerebral haemorrhage (ICH). Our aim was to assess the safety and efficiency of this treatment, as a run-in phase to a larger trial. METHODS Patients who had acute spontaneous ICH diagnosed by CT within 6 h of onset, elevated systolic(More)
This paper proposes a complete framework of posterior probability support vector machines (PPSVMs) for weighted training samples using modified concepts of risks, linear separability, margin, and optimal hyperplane. Within this framework, a new optimization problem for unbalanced classification problems is formulated and a new concept of support vectors(More)
Recently increasing attention has been focused on directly optimizing ranking measures and inducing sparsity in learning models. However, few attempts have been made to relate them together in approaching the problem of learning to rank. In this paper, we consider the sparse algorithms to directly optimize the Normalized Discounted Cumulative Gain (NDCG)(More)
The ideas from fuzzy neural networks and support vector machine (SVM) are incorporated to make SVM classifiers perform better. The influence of the samples with high uncertainty can be decreased by employing the fuzzy membership to weigh the margin of each training vector. The linear separability, fuzzy margin, optimal hyperplane, generalization and soft(More)
A novel neural network is proposed in this paper for realizing associative memory. The main advantage of the neural network is that each prototype pattern is stored if and only if as an asymptotically stable equilibrium point. Furthermore, the basin of attraction of each desired memory pattern is distributed reasonably (in the Hamming distance sense), and(More)
Previous mutation and modeling studies have identified an aromatic cluster in the transmembrane helix (TMH) 3-4-5 region as important for ligand binding at the CB(1) and CB(2) cannabinoid receptors. Through novel mixed mode Monte Carlo/Stochastic Dynamics (MC/SD) calculations, we tested the importance of aromaticity at position 5.39(275) in CB(1). MC/SD(More)