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Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio.
TLDR
It is concluded that pinocembrin exerts its neuroprotective effects in glutamate injury model partly by inhibiting p53 expression, thus Bax-Bcl-2 ratio, and the release of cytochrome c. Expand
Effective compounds group of Mongolian prescriptions BAIMAI-SAN protect against peripheral neuropathy in lower limbs of rats through neuro protective effect.
TLDR
It is first report that ECGBM could protect the peripheral neuron in diabetic rat in vivo and in vitro, and this activity may be associated with the neuron protective effect. Expand
The novel mechanism of recombinant human ciliary neurotrophic factor on the anti-diabetes activity.
TLDR
New mechanisms of the activity and mechanisms on anti-diabetes of rhCNTF are indicated, which may be a novel anti- diabetes reagent partly acting by enhancing energy metabolism. Expand
The Effect of Estrogen Replacement Therapy on Alzheimer's Disease and Parkinson's Disease in Postmenopausal Women: A Meta-Analysis
TLDR
Evidence is presented here to support the use of estrogen therapy for the treatment of AD and PD and to show that study design and measure of effect were the source of heterogeneity. Expand
[Application of network pharmacology and high through-put technology on active compounds screening from traditional Chinese medicine].
OBJECTIVE To solve the difficult in the active compounds screening from traditional Chinese medicines (TCM). METHOD According to preliminary lab results and related literature, systematic analysisExpand
Recombinant human ciliary neurotrophic factor reduces weight partly by regulating nuclear respiratory factor 1 and mitochondrial transcription factor A.
TLDR
The result indicates that rhCNTF can enhance the expressions of NRF-1 and TFam, both of which can up-regulate the expression of UCP-1, which may be associated with remedying obesity. Expand
Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson's Disease
Parkinson's disease (PD) is a common and complex neurodegenerative disease; the pathogenesis of which is still uncertain. Exosomes, nanosized extracellular vesicles, have been suggested toExpand
Determination of hyperoside and isoquercitrin in rat plasma by membrane-protected micro-solid-phase extraction with high-performance liquid chromatography.
TLDR
Compared with traditional methods, solid-phase extraction, liquid-liquid extraction and protein precipitation, the developed method was simple, highly efficient for extraction, environmentally friendly, and particularly suitable for complex biological samples. Expand
Ellagic acid protects against neuron damage in ischemic stroke through regulating the ratio of Bcl-2/Bax expression.
TLDR
Treatment of ellagic acid resulted in increased neuron viability, cell nuclear integrity, and the ratio of Bcl-2/Bax expression in the primary cultured neuron model; EA treatment also lead to a decrease in the number of apoptotic cells. Expand
Genome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia.
TLDR
The first genome-wide microRNA expression profiling in serum-derived exosome from 49 first-episode, drug-free SCZ patients and 46 controls was performed and identified miRNAs and co-regulated modules that were perturbed in SCZ. Expand
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