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Type 1 diabetes (T1D) in non-obese diabetic (NOD) mice may be favored by immune dysregulation leading to the hyporesponsiveness of regulatory T cells and activation of effector T-helper type 1 (Th1) cells. The immunoregulatory activity of natural killer T (NKT) cells is well documented, and both interleukin (IL)-4 and IL-10 secreted by NKT cells have(More)
OBJECTIVE Endocardial fibroelastosis (EFE), a common pediatric cardiovascular disease, often results in chronic heart failure (CHF) and death. Clinical trials have shown that the regimen of combining beta-adrenoreceptor blocker with traditional medicines against CHF can improve left ventricular function and prevent the ventricle from remodeling in patients(More)
Spatially and temporally regulated somatic mutations can be achieved by using the Cre/loxP recombination system of bacteriophage P1. To develop a cell type-specific system of gene targeting in the peripheral nervous system, we generated the transgenic mouse lines expressing Cre recombinase under the control of the mouse peripherin gene promoter. The(More)
Since the discovery of the first mammalian microRNA (miRNA) more than two decades ago, a plethora of miRNAs has been identified in humans, now amounting to more than 2500. Essential for post-transcriptional regulation of gene networks integral for developmental pathways and immune response, it is not surprising that dysregulation of miRNAs is often(More)
Background: Although many software engineering methodologies and guidelines are provided, it is common that developers apply their very own programming styles to the source code being produced. These individually preferred programming styles are more comprehensive for themselves, but may well conflict with each other. Thus, the problem of stylistic(More)
A number of research efforts have focused in the area of programming style. However, to the best of our knowledge, there is little sound and solid evidence of how and to what extent can stylistic inconsistency impact the readability and maintainability of the source code. To bridge the research gap, we design an empirical experiment in which eye tracking(More)
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