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INTRODUCTION Serum creatinine is a late marker of acute kidney injury (AKI). Urine neutrophil gelatinase-associated lipocalin (uNGAL) is an early marker of AKI, where the timing of kidney injury is known. It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in(More)
Acute renal failure (ARF) secondary to ischemic injury remains a common and potentially devastating problem. A transcriptome-wide interrogation strategy was used to identify renal genes that are induced very early after renal ischemia, whose protein products might serve as novel biomarkers for ARF. Seven genes that are upregulated >10-fold were identified,(More)
Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial roles in cardiac development and disease. Here, we combined patient-derived and genetically engineered induced pluripotent stem cells (iPSCs) with tissue engineering to elucidate the pathophysiology underlying the cardiomyopathy of Barth syndrome (BTHS), a mitochondrial(More)
In this paper we describe a method of acquiring word order fl'om corpora. Word order is defined as the order of modifiers, or the order of phrasal milts called 'bunsetsu' which depend on the stone modifiee. The method uses a model which automatically discovers what the tendency of the word order in Japanese is by using various kinds of information in and(More)
We constructed a system for answering non-factoid Japanese questions. We used passage retrieval methods for the system. We extracted paragraphs based on terms from an input question and output them as the desired answer. We classified the non-factoid questions into six categories. We used a particular method for each category. For example, we increased the(More)
  • Yan Zhang, Xing Fen Wang, Ze Guo Ding, Qing Ma, Gui Rong Zhang, Shu Ling Zhang +4 others
  • 2013
Verticillium wilt, caused by the fungal pathogen Verticillium dahliae, is the most severe disease in cotton (Gossypium spp.), causing great lint losses worldwide. Disease management could be achieved in the field if genetically improved, resistant plants were used. However, the interaction between V. dahliae and cotton is a complicated process, and its(More)
  • Bin Zhou, Qing Ma, Satish Rajagopal, Sean M Wu, Ibrahim Domian, José Rivera-Feliciano +5 others
  • 2008
The heart is formed from cardiogenic progenitors expressing the transcription factors Nkx2-5 and Isl1 (refs 1 and 2). These multipotent progenitors give rise to cardiomyocyte, smooth muscle and endothelial cells, the major lineages of the mature heart. Here we identify a novel cardiogenic precursor marked by expression of the transcription factor Wt1 and(More)
INTRODUCTION Acute kidney injury (AKI) is a frequent complication of cardiopulmonary bypass (CPB). The lack of early biomarkers has impaired our ability to intervene in a timely manner. We previously showed in a small cohort of patients that plasma neutrophil gelatinase-associated lipocalin (NGAL), measured using a research enzyme-linked immunosorbent(More)