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MicroRNAs are dynamically regulated in hypertrophic hearts, and miR‐199a is essential for the maintenance of cell size in cardiomyocytes
Cardiac hypertrophy, which is characterized by an increase in cell size and reactivation of fetal genes, occurs as an adaptive response to diverse forms of stress and often results in heart failure… Expand
Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
Aims/hypothesisSirtuin-1 (SIRT1) is a potential therapeutic target to combat insulin resistance and type 2 diabetes. This study aims to identify a microRNA (miRNA) targeting SIRT1 to regulate hepatic… Expand
Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.
- L. Gao, L. Chen, +8 authors H. Yang
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 June 2014
Inhibition of matrix metalloproteinases-2 (MMP-2) activation renders cardioprotection from ischemia/reperfusion (I/R) injury; however, the signaling pathways involved have not been fully understood.… Expand
Non-coding RNAs as biomarkers for acute myocardial infarction
Acute myocardial infarction (AMI) is a main threat to human lives worldwide. Early and accurate diagnoses warrant immediate medical care, which would reduce mortality and improve prognoses.… Expand
The Dynamic Monitoring on Mining Collapsing around Xinglongzhuang Coal Mine Based on Remote Sensing Images
A large number of old coal mine, such as Xinglongzhuang coal mine, made a great contribution to local economic development and national construction. But, serious mining collapsing was caused also,… Expand