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AIMS We investigated the effect of the water extract of Salacia oblonga (SOE), an ayurvedic antidiabetic and antiobesity medicine, on obesity and diabetes-associated cardiac hypertrophy and discuss the role of modulation of cardiac angiotensin II type 1 receptor (AT(1)) expression in the effect. METHODS SOE (100 mg/kg) was given orally to male Zucker(More)
Although immunosuppressive treatments are available for acute cardiac rejection no viable treatment exists for long-term cardiac graft failure. Moreover, the extended use of calcineurin inhibitor immunosuppressants, the mainstay of current treatment for cardiac transplantation, leads to significant side effects such as nephrotoxicity and an increased risk(More)
Memory T cells present a unique challenge in transplantation. Although memory T cells express robust immune responses to invading pathogens, they may be resistant to the effects of immunosuppressive therapies used to prolong graft survival. In previous studies, we found that compound K, the synthesized analogue of highly unsaturated fatty acids from Isatis(More)
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR‑TKIs) have shown promising effects against the growth of non-small cell lung cancer (NSCLC) cells harboring EGFR mutations (EGFR‑mts). However, many patients with NSCLC that are accepted for EGFR‑TKI treatment followed by chemotherapy possess an unknown EGFR status including wild-type EGFR(More)
Post buckling problem of a large deformed beam is analyzed using canonical dual finite element method (CD-FEM). The feature of this method is to choose correctly the canonical dual stress so that the original non-convex potential energy functional is reformulated in a mixed complementary energy form with both displacement and stress fields, and a pure(More)
The self-assembly of nanomaterials into three-dimensional hierarchical structures is a fundamental step impacting a large number of synthetic and natural processes. These range from the scalable fabrication of nano-devices such as batteries, sensors and third generation solar cells to the uptake and accumulation of particulate pollution in the lung alveoli.(More)
Multidrug resistance (MDR) is a key element in the failure of chemotherapies, and development of agents to overcome MDR is crucial to improving cancer treatments. The overexpression of glutathione-S-transferases (GSTs) is one of the major mechanisms of MDR. Because some agents used in traditional Chinese medicine have strong antitumor effects coupled with(More)
BACKGROUND SUMO-activating enzyme subunit 2 (SAE2) is the sole E1-activating enzyme required for numerous important protein SUMOylation, abnormal of which is associated with carcinogenesis. SAE2 inactivation was recently reported to be a therapeutic strategy in cancers with Myc overexpression. However, the roles of SAE2 in small cell lung cancer (SCLC) are(More)
OBJECTIVE Despite the amply evidence and guidelines in treating coronary artery disease (CAD) with lipid-lowering therapy, physicians still have concerns in treating acute myocardial infarction (AMI) patients who have the low serum lipid level. We explored the adequacy of lipid-lowering therapy in treating AMI patients. PATIENTS AND METHODS Over 3000 CAD(More)