Qing-Gang Ji

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On the basis of the chemical structure of daidzein, a series of isoflavones have been synthesized. The intermediates, 7-methoxy-4'-hydroxy-isoflavone(V) and 7-hydroxy-4'-methoxyisoflavone(IX) were prepared by condensation of corresponding desoxybenzoin with dimethylformamide dimethylacetal. 7-Methoxy-2-methyl-4'-hydroxyisoflavone (VII) was also prepared(More)
A series of new coumarin-based benzotriazole derivatives were successfully synthesized via a multi-step sequence of cyclization, etherification and N-alkylation, and were confirmed by 1H NMR, IR, MS spectra as well as elemental analyses. All these synthesized coumarin compounds were evaluated for in vitro antimicrobial activities against four Gram-positive(More)
A series of novel 1-methyl-3-substituted quinazoline-2,4-dione derivatives was designed, synthesized, and evaluated for their antimicrobial activities against six strains of bacteria and five fungi in vitro. The synthesized compounds were characterized by spectral methods. The bioactive assays showed that most of the compounds exhibited moderate(More)
A series of novel quinolin-2(1H)-one derivatives were synthesized and characterized by IR, 1H NMR, 13C NMR, and MS spectral data. All the new compounds were screened for their antimicrobial activities against six trains of bacteria and five fungi in vitro by twofold serial dilution technique. The bioactive assay showed that most of the compounds exhibited(More)
In the title compound, C(20)H(20)Cl(2)N(4)O(2), the nitro-imidazole ring makes dihedral angles of 17.00 (1) and 60.45 (11)° with the phenyl and chloro-phenyl rings, respectively. The three-coordinate N atom connected to two methyl-ene and one methine C atoms shows pyramidal coordination.
A series of novel N-acyl substituted quinolin-2(1H)-one derivatives were synthesized and screened in vitro for their antibacterial and antifungal activities by disc diffusion method. All the compounds exhibited moderate to good antimicrobial activities, some of these compounds displayed comparable or better antibacterial or antifungal activities against(More)
A series of dihydroindoline compounds were synthesized. The N-alkylation and O-acylation were controlled selectively by the presence or absence of phase transfer catalyst. The structure of compounds synthesized were ascertained by elemental analyses, 1HNMR, MS, and IR. The anticholinesterase activity was determined by modified Hestrin method and their pCI50(More)