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PURPOSE Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The potency and selectivity of various classes of PDE inhibitors on purified rod and cone PDE6 and on intact rod outer segments (ROS) were characterized. METHODS The inhibition constant(More)
Energy is a bottleneck in smart phone systems, and knowing the status of the battery lifetime and being able to use it efficiently is an important requirement from users. We propose a system context-aware approach for predicting battery lifetime, which allows a user to know the accurate battery status and to utilize the power efficiently. We refer to a(More)
Shear modulus estimation can be confounded by the ill-posed nature of the inverse elasticity problem. In this paper, we report the results of experiments conducted on simulated and gelatin phantoms to investigate the effect of various parameters (i.e., regularization, spatial filtering and the subzone generation process) associated with shear modulus(More)
Facioscapulohumeral muscular dystrophy (FSHD) is a muscular dystrophy caused by inefficient epigenetic repression of the D4Z4 macrosatellite array and somatic expression of the DUX4 retrogene. DUX4 is a double homeobox transcription factor that is normally expressed in the testis and causes apoptosis and FSHD when misexpressed in skeletal muscle. The(More)
(-)-epigallocatechin-3-gallate (EGCG) is a well-known cancer chemopreventive agent. The potential mechanisms include regulation of multiple molecules. Carcinogenesis in lung cancer is related to the imbalance of tumor suppressor and oncogene. JWA is a structurally novel microtubule-binding protein and is a potential tumor suppressor. DNA topoisomerase IIα(More)
Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 expression would(More)
Cancer is a major disease worldwide and different approaches are needed for its prevention. Previous laboratory and clinical studies suggest that cancer can be prevented by chemicals, including those from the diet. Furthermore, epidemiological studies have suggested that deficiencies in certain nutrients can increase the risk of some cancers. In this(More)
Attention is considered a central component of cognitive functioning. While many studies have demonstrated that eye direction can trigger reflexive attention shifting, there have been few studies on gender differences in attention shifting. To explore this issue we present results from an event-related potential (ERP) experiment using the spatial cueing(More)