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Genome-wide assessment of differential translations with ribosome profiling data
The closely regulated process of mRNA translation is crucial for precise control of protein abundance and quality. Ribosome profiling, a combination of ribosome foot-printing and RNA deep sequencing,Expand
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells (SSCs) produce haploid spermatozoa. This highly specialized process is precisely controlled at theExpand
Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response
Elevated expression of RNA binding protein HNRNPC has been reported in cancer cells, while the essentialness and functions of HNRNPC in tumors were not clear. We showed that repression of HNRNPC inExpand
Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling
  • Qin Zou, Zhengtao Xiao, +4 authors Xuerui Yang
  • Biology, Medicine
  • Theranostics
  • 31 May 2019
Despite the critical position of translation in the multilevel gene expression regulation program, high-resolution and genome-wide view of the landscape of RNA translation in solid tumors is stillExpand
Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli
TLDR
We conducted ribosome profiling in parallel with RNA-Seq to investigate the alterations in transcription and translation efficiency when E. coli cells were exposed to a mild heat stress (from 30°C to 45 °C). Expand
COPII mitigates ER stress by promoting formation of ER whorls
Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report formation of ER whorls as an effector mechanism of the ER stress response. We found that strong ER stress inducesExpand
Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells
Dear Editor, Migrasomes are recently discovered vesicular organelles which form on the retraction fibers (RFs) of migrating cells. Once detached from cells, migrasomes can rupture and release theirExpand