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Functional analysis of mammalian genes in vivo is primarily achieved through analysing knockout mice. Now that the sequencing of several mammalian genomes has been completed, understanding functions of all the genes represents the next major challenge in the post-genome era. Generation of knockout mutant mice has currently been achieved by many research(More)
We d escribe an improved method of integrating a udio and visual information in a HMM-based audiovisual ASR system. The m ethod uses a modied semicontinuous HMM (SCHMM) for integration and recognition. Our results show substantial improvements over earlier integration methods at high noise levels. Our integration method relies on the assumption that, as(More)
The majority of gene-targeting experiments in mice are performed in 129Sv-derived embryonic stem (ES) cell lines, which are generally considered to be more reliable at colonizing the germ line than ES cells derived from other strains. Gene targeting is reliant on homologous recombination of a targeting vector with the host ES cell genome. The efficiency of(More)
The efficient, stable delivery of siRNA into cells, and the appropriate controls for non-specific off-target effects of siRNA are major limitations to functional studies using siRNA technology. To overcome these drawbacks, we have developed a single lentiviral vector that can concurrently deplete endogenous gene expression while expressing an epitope-tagged(More)
Based on the principle of innovative alliance formation process of virtual enterprise cooperative projects, the risk management models including the process of brainchild project market risk and virtual enterprise project cooperation design, co-manufacturing process, and co-marketing process are established. Also, their risk factors definition,(More)
For deeply understanding the acceptance and use of Chinese SciencePaper Online (CSO), this study developed a research framework to identify factors that would influence the acceptance and use of CSO using the Technology Acceptance Model (TAM) and the Theory of Planned Behavior (TPB). A model with 6 constructs and 7 paths are constructed considering both(More)