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Considerable evidence suggests that proinflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report that the let7 repressor LIN28B and its regulator IKBKB (IKKb) sustain cancer cell stemness by interacting with the Wnt/TCF7L2 (TCF4) signaling pathway to promote cancer(More)
Result-chain based modeling is a new system analysis and process modeling method. This paper defines node influence degree (NID) to evaluate importance of nodes in a system (RCM model), so to help people to understand the system better. Both qualitative and quantitative evaluation method are described. In the qualitative evaluation method, out-degree and(More)
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