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Two-component signal transduction systems (TCSs) play fundamental roles in bacterial survival and pathogenesis and have been proposed as targets for the development of novel classes of antibiotics. A new coupled assay was developed and applied to analyse the kinetic mechanisms of three new kinds of inhibitors of TCS function. The assay exploits the(More)
This article focuses on the approximation of conventional second order derivative via the combined (diamond-α) dynamic derivative on time scales with necessary smoothness conditions embedded. We will show the constraints under which the second order dynamic derivative provides a consistent approximation to the conventional second derivative; the cases where(More)
Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian(More)
Metallothionein (MT) gene therapy leads to resolution of liver fibrosis in mouse model, in which the activation of collagenases is involved in the regression of liver fibrosis. MT plays a critical role in zinc sequestration in the liver suggesting its therapeutic effect would be mediated by zinc. The present study was undertaken to test the hypothesis that(More)
Soft-partition-weighted-sum (Soft-PWS) filters are a class of spatially adaptive moving-window filters for signal and image restoration. Their performance is shown to be promising. However, optimization of the Soft-PWS filters has received only limited attention. Earlier work focused on a stochastic-gradient method that is computationally prohibitive in(More)