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Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis
A transport model that involves a substantial conformational change of FolT is proposed, and two conserved XRX motifs from the coupling helices of EcfT have a vital role in energy coupling by docking into EcfA–EcfA′.
Bioassay and ultraperformance liquid chromatography/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthone from the pericarp of Garcinia yunnanensis Hu.
It is noteworthy that oblongifolin C (4), the major constituent of this plant, has proved to be the most active one among the isolates for inducing apoptotic cell death in cervical cancer derived HeLa-C3 sensor cells.
New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic…
New cytotoxic and anti-inflammatory compounds isolated from Morus alba L.
Six Diels–Alder adducts and nine prenylated flavanones were isolated from the root bark of Morus alba L and soroceal B and sanggenol Q were new compounds, which were elucidated on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques.
Novel Diterpenoids from Salvia dugesii
Two novel rearranged clerodane diterpenoids, dugesin A (1) and dugesin B (2), were isolated from the aerial parts of Salvia dugesii, together with five known clerodane diterpenoids: isosalvipuberulin…
Vibsanin B Preferentially Targets HSP90β, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
It is demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS and is a promising drug lead for treating inflammation-associated diseases.
Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis
Two new tirucallane triterpenoids, aquilacallanes A–B and 5,7,4′-trimethoxyflavone, together with 15 known compounds were isolated from the leaves of Aquilaria sinensis and their structures were elucidated on the basis of extensive spectroscopic analyses.
Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.
Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C, were isolated from Schisandra micrantha, and the potent anti-HIV-1 activity and unique structural features of make it a promising lead for therapeutic development of a new generation of anti-hIV drug.
Two new abietane diterpenoids from Salvia yunnanensis.
Two new abietane diterpenoids, yunnannin A and danshenol C, were isolated from Salvia yunnanensis and their structures were established based on spectroscopic data, chemical reactions and comparison with literature data.