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Gender-preferential gene expression is a widespread phenomenon in humans. It is important to study how gender differences influence the pathogenesis of various diseases and response to specific drugs. The aim of this study is to determine if the mouse albumin enhancer/promoter may serve as the promoter to introduce gender-preferential gene expression in(More)
Epigenetic heritability is an important issue in the field of genetics and also in the development of many human diseases. In this study, we created a transgenic rat model and investigated the transgenerational methylation patterns in these animals. The transgene DNA fragment was unmethylated before it was injected into the pronucleus, so it is a good model(More)
BACKGROUND The use of DNA from archival formalin and paraffin embedded (FFPE) tissue for genetic and epigenetic analyses may be problematic, since the DNA is often degraded and only limited amounts may be available. Thus, it is currently not known whether genome-wide methylation can be reliably assessed in DNA from archival FFPE tissue. (More)
Endometrial carcinoma is the most common gynecologic malignancy in both developed and some developing countries. Unlike cervical cancer, for which there is routine screening, only patients symptomatic for endometrial carcinoma typically seek medical help for its diagnosis and treatment. Dilatation and curettage (D&C) has been the standard procedure for(More)
1. Howie, B. et al. Nat. Genet. 44, 955–959 (2012). 2. Delaneau, O., Marchini, J. & Zagury, J.F. Nat. Methods 9, 179–181 (2012). 3. Howie, B.N., Marchini, J. & Stephens, M. G3 1, 457–470 (2011). 4. Williams, A.L. et al. Am. J. Hum. Genet. 91, 238–251 (2012). 5. Browning, S.R. & Browning, B.L. Am. J. Hum. Genet. 81, 1084–1097 (2007). 6. Li, Y. et al. Genet.(More)
We recently discovered a dynamic copy number variation on the NCF1 (neutrophil cytosolic factor 1) pseudogenes in human populations. In this study, we investigated whether these pseudogenes are functional or junk as described before. We sequenced the RNAs transcribed from the genome of this locus, and discovered over 10 splicing isoforms from the NCF1(More)
INTRODUCTION Enhancer of zeste homolog 2 (EZH2) has been reported to be associated with biological malignancy in several cancers. High expression of EZH2 is associated with tumor cell proliferation, invasion and metastasis and has important clinicopathologic significance. However, little is known about the function and mechanisms of EZH2 in cervical cancer.(More)
BACKGROUND C-reactive protein (CRP) is a marker of inflammation and a risk predictor of cardiovascular disease. Current CRP assays are focused on the quantification of the CRP levels as pentamers. However, CRP can be present as other multimeric forms. There will be a market need to measure the CRP multimeric structure in addition to the levels in human(More)
Porous- and hollow-structured LiNb3O8 anode material was prepared by a hydrothermal-assisted sintering strategy for the first time. The phase evolution was studied, and the formation mechanism of the porous and hollow structure was proposed. The formation of the unique structure can be attributed to the local existence of liquid phase because of the(More)
Nine compounds were isolated from Nocardia sp. YIM 64630, and their structures were elucidated as 5'-O-acetyl-2'-deoxyuridine (1), 22E,24R-5α,6α-epoxyergosta-8(14),22-diene-3β,7α-diol (2), 22E,24R-5α,6α-epoxyergosta-8,22-diene-3β,7α-diol (3), 22E,24R-ergosta-7,22-diene-3β,5α,6β-triol (4), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (5),(More)