Qilin Zhang

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BACKGROUND Mounting evidence shows that urate may become a biomarker of Parkinson's disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy. However, the cellular and molecular mechanisms underlying its neuroprotective actions remain poorly understood. RESULTS In this study, we showed that urate pretreatment protected(More)
Macrophage migration inhibitory factor (MIF) is an essential regulator of the macrophage responses to endotoxin. MIF also has the ability to override the anti-inflammatory actions of glucocorticoids during an immune response, and is thus an important pro-inflammatory factor. The presence of MIF in cells of the anterior pituitary has been described, and high(More)
Higher plasma urate level is reported to be associated with a reduced risk and slower progression of Parkinson's disease (PD). In this study, we explored the effects of urate on dopaminergic neurons in nigrostriatal pathway in the 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats. Uric acid (UA), when given twice daily at 200 mg/kg intraperitoneally for(More)
We examine an under-explored visual recognition problem, where we have a main view along with an auxiliary view of visual information present in the training data, but merely the main view is available in the test data. To effectively leverage the auxiliary view to train a stronger classifier, we propose a collaborative auxiliary learning framework based on(More)
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of corticotrophin-dependent Cushing's syndrome cases. However, the genetic alterations in this disease are unclear. Here, we performed whole-exome sequencing of DNA derived from 12(More)
  • Dongshuai Li, Mohammad Azadifar, Farhad Rachidi, Marcos Rubinstein, Mario Paolone, Davide Pavanello +3 others
  • 2016
—In this paper, we present a theoretical analysis of the propagation effects of lightning electromagnetic fields over a mountainous terrain. The analysis is supported by experimental observations consisting of simultaneous records of lightning currents and electric fields associated with upward negative lightning flashes to the instrumented Säntis tower in(More)
TO THE EDITOR Psoriasis is a common, chronic, inflam-matory, organ-specific autoimmune skin disease with a complex genetic background (Nestle et al., 2009; Zhang et al., 2013). Psoriasis vulgaris (PsV) is the most common type, accounting for approximately 85–90% of all psoriasis patients, and characterized by raised, well-demarcated, erythematous oval(More)
BACKGROUND Interleukin 17 (IL-17) is a proinflammatory cytokine produced by a new subset of activated CD4+ T cells, Th17 cells. We previously showed that increased Th17 cell populations were presented in human medulloblastoma-infiltrating T cells and peripheral blood. In this study, we attempted to address the possible role of Th17 cells in the biologic(More)