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BACKGROUND Generalized pustular psoriasis (GPP) is a rare type of psoriasis with potentially life-threatening implications. Mutations in IL36RN gene have been suggested to be causative or predisposing factors for GPP. OBJECTIVE To evaluate the genetic heterogeneity of GPP, PV and GPP alone, GPP with PV. METHODS We performed a sanger sequencing identify(More)
The difficulty of predicting the efficacy of somatostatin analogs (SSA) is not fully resolved. Here, we quantitatively evaluated the predictive value of relative signal intensity (rSI) on T1- and T2-weighted magnetic resonance imaging (MRI) for the short-term efficacy (3 months) of SSA therapy in patients with active acromegaly and assessed the correlation(More)
We examine an under-explored visual recognition problem, where we have a main view along with an auxiliary view of visual information present in the training data, but merely the main view is available in the test data. To effectively leverage the auxiliary view to train a stronger classifier, we propose a collaborative auxiliary learning framework based on(More)
Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered.(More)
This paper presents a series of user parameter-free iterative Sparse Asymptotic Minimum Variance (SAMV) approaches for array processing applications based on the asymptotically minimum variance (AMV) criterion. With the assumption of abundant snapshots in the direction-of-arrival (DOA) estimation problem, the signal powers and noise variance are jointly(More)
TO THE EDITOR Psoriasis is a common, chronic, inflam-matory, organ-specific autoimmune skin disease with a complex genetic background (Nestle et al., 2009; Zhang et al., 2013). Psoriasis vulgaris (PsV) is the most common type, accounting for approximately 85–90% of all psoriasis patients, and characterized by raised, well-demarcated, erythematous oval(More)
Tripartite motif (TRIM) 22 plays an important role in IFN-mediated antiviral activity. We previously demonstrated that IFN regulatory factor-1 (IRF-1) was crucial for constitutive and IFN-induced TRIM22 expression via binding to a special cis-element named 5' extended IFN-stimulating response element. Here, we further investigate the molecular mechanisms of(More)
Pituitary adenoma is one of the most common intracranial neoplasms, and its genetic basis remains largely unknown. To identify genetic susceptibility loci for sporadic pituitary adenoma, we performed a three-stage genome-wide association study (GWAS) in the Han Chinese population. We first analyzed genome-wide SNP data in 771 pituitary adenoma cases and(More)