• Publications
  • Influence
Proteolytic processing of Alzheimer's β-amyloid precursor protein.
β-Amyloid precursor protein (APP) is a critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post-translational proteolysis/processing to generate the hydrophobic β-amyloidExpand
  • 231
  • 17
Changes in cerebral glucose metabolism in patients with mild-to-moderate Alzheimer's disease: A pilot study with the Chinese herbal medicine fuzhisan
The aim of this study was to investigate the effects of fuzhisan (FZS, 10mg/day), a Chinese herbal medicine, on cerebral glucose metabolism and neuropsychological metrics in patients withExpand
  • 22
  • 2
M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation
A prime culprit in the pathogenesis of Alzheimer's disease (AD) is overproduction/aggregation of β-amyloid (Aβ), which is derived from β-Amyloid Precursor Protein through sequential cleavages byExpand
  • 18
  • 2
P268S in NOD2 associates with susceptibility to Parkinson’s disease in Chinese population
BackgroundThe cause of almost all cases of Parkinson’s disease (PD) remains unknown. Recent years have seen an explosion in the rate of discovery of genetic defects linked to PD. Different racial andExpand
  • 14
  • 2
Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window
OBJECTIVE To determine the safety and efficacy of combined local mild hypothermia and IV rtPA in treating acute ischemic stroke (AIS) patients with MRI perfusion- and diffusion-weighted imagingExpand
  • 26
  • 2
Association of MTHFR C677T Polymorphism with Susceptibility to Migraine in the Chinese population
A number of genes have been implicated in the pathogenesis of migraine, a common neurological disorder also in China. However, data on association of genetic variations with migraine susceptibilityExpand
  • 20
  • 2
Case-control study of GRIA1 and GRIA3 gene variants in migraine
BackgroundAs the most abundant excitatory neurotransmitter in the central nervous system, glutamate has been accepted to play a major role in the pathophysiology of migraine. The previous studiesExpand
  • 11
  • 1
New evidence for involvement of ESR1 gene in susceptibility to Chinese migraine
Migraine is a common and disabling nervous system disease with a significant genetic predisposition. The sex hormones play an important role in the pathogenesis of migraine. However, the conclusionsExpand
  • 7
  • 1
Gene diagnosis of Oculopharyngeal muscular dystrophy in a Chinese family by a genescan method
This study aims to perform gene diagnosis for Chinese family patients with Oculopharyngeal muscular dystrophy (OPMD). Genomic DNAs were extracted from the pedigrees' members. Gene diagnosis wasExpand
  • 5
  • 1
Effect of local mild hypothermia on regional cerebral blood flow in patients with acute intracerebral hemorrhage assessed by 99mTc-ECD SPECT imaging.
OBJECTIVE This study aimed to observe the effect of local mild hypothermia on regional cerebral blood flow (rCBF) after acute intracerebral hemorrhage (ICH) and to evaluate its relation to clinicalExpand
  • 7