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OBJECTIVE It is reported that transforming growth factor beta1 (TGF-beta1) has the protective effects on the articular cartilage in osteoarthritis (OA). To investigate the significance of the expressions of matrix metalloproteinase 9 (MMP-9), TGF-beta1 mRNA and corresponding proteins in OA. METHODS The specimens of articular cartilage and synovium were(More)
Chondrogenic differentiation of mesenchymal stem cells (MSCs) in vitro usually requires the presence of growth factors in the culture condition. But many cost-effect methods can successfully fulfill this without addition of these cytokines. This article focuses upon the effect of non-growth factors on the chondrogenic differentiation of MSCs and the concise(More)
Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum,(More)
OBJECTIVE To review the research progress of promoting the bone formation at early stage by components of the extracellular matrix (ECM). METHODS Recent literature concerning the influence of these components on new bone formation and bone/implant contact was extensively reviewed and summarized. RESULTS Coating of titanium or hydroxyapatite implants(More)
OBJECTIVE To comprehend the pathological features and possible pathogenesis ot avascular necrosis of the femoral head (ANFH) by morphology and immunohistochemical observation of osterix (OSX) and adiponectin through in vitro traumatic and non-traumatic ANFH specimens, so as to provide a theoretical basis for clinical treatment. METHODS Sixty-six ANFH(More)
Fast and stable repair of segmental bone defects remains a challenge for clinical orthopedic surgery. In recent years, porous tantalum has been widely applied in clinical orthopedics for low modulus of elasticity, with three-dimensional microstructures similar to cancellous bone and excellent biocompatibility. To further improve bone the repairing ability(More)
OBJECTIVE To investigate the expression levels and significance of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in rabbit radius defects repaired with allogeneic and autogenic bone. METHODS Forty adult New Zealand rabbits were chosen, and 10 mm bone defect model was created in the bilateral radii of 28 experimental rabbits. The(More)
OBJECTIVE To investigate the feasibility of the domestic porous tantalum as scaffold material of bone tissue engineering by observing the expressions of osteogenesis related factors of MG63 cells co-cultured with domestic porous tantalum. METHODS MG63 cells were cultured with porous tantalum scaffolds (group A), with porous tantalum leaching solution(More)
OBJECTIVE To evaluate the effect of implantation of the complex of high viscous chitosan/glycerol phosphate with demineralized bone matrix (HV-C/GP-DBM) in repairing cartilage defects of rabbits. METHODS HV-C/GP-DBM was prepared by compounding HV-C/GP and DBM by 2:1 (W/W). Twenty-four 34-week-old New Zealand white adult rabbits, weighing 3.5-4.5 kg, were(More)
OBJECTIVE To investigate the adhesiveness of osteoblasts and vascular endothelial cells from rat BMSCs. METHODS The BMSCs were isolated from 4-week-old SD co-cultured on allogeneic freeze-dried partially bone in vitro. rats (weighing 100-110 g) and cultured in vitro. The third generation of BMSCs were induced into osteoblasts and vascular endothelial(More)