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UNLABELLED Hepatoblastoma (HB) is the most common primary liver tumor in children. Mutations in the β-catenin gene that lead to constitutive activation of the Wnt pathway have been detected in a large proportion of HB tumors. To identify novel mutations in HB, we performed whole-exome sequencing of six paired HB tumors and their corresponding lymphocytes.(More)
PURPOSE To identify the levels of functional immunity measured by the ImmuKnow assay in Chinese liver transplantation recipients and its application in monitoring the risk of posttransplant infection. METHODS Forty-five apparent healthy Chinese and 106 adult liver transplant (LT) recipients were under investigation. LTs were grouped in stable status or(More)
OBJECTIVE The aim of this study was to assess serum levels of presurgical α-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) as prognostic markers in patients with hepatic carcinoma after liver transplantation (LT). METHODS A total of 226 patients were recruited for the analysis of serum AFP and CA19-9 levels, on the basis of which the tumor(More)
Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and promotes drug resistance of HCC cells. By(More)
PURPOSE To study the reliability of digital slit lamp microscope as a tool for quantitative analysis in one dimensional size measurement. METHODS Three single-blinded observers acquired and repeatedly measured the images with a size of 4.00 mm and 10.00 mm on the vernier caliper, which simulatated the human eye pupil and cornea diameter under China-made(More)
The purpose of the current study was to identify novel mutations in the FRMD7 (FERM domain containing 7) gene and to characterize clinical features in Chinese patients with congenital motor nystagmus. For this purpose, 18 patients with congenital motor nystagmus were selected from the ocular genetic diseases bank of the Pediatric and Genetic Clinic of(More)
PURPOSE To investigate the clinical manifestation of damage of visual function caused by pituitary adenoma. METHODS Visual acuity, visual field, fundus fluorescein angiography (FFA), pattern visual evoked potential (PVEP) and examination fundus were performed in 126 cases (252 eyes) of pituitary tumor. RESULTS There was 73.8% (186 eyes) of patients with(More)
Little information is available regarding the impact of cytochrome P450 (CYP) 3A5 on the metabolism of TAC in infant LTx. Therefore, the CYP3A5 genotype of Chinese pediatric recipients (intestine) as well as donors (graft liver) was performed for the purpose of establishing an optimal dosage regimen in children. Sixty-four patients were divided according to(More)
We aimed to assess the impact of size mismatching between grafts and recipients on outcomes of infants or small children after LDLT. Between October 2006 and December 2014, 129 LDLT recipients weighing no more than 8 kg were retrospectively analyzed. The entire cohort was categorized into three groups by GRWR: GRWR < 3.0% (group A, n = 38), 3.0% ≤ GRWR <(More)
OBJECTIVE To evaluate the therapeuitic effects of phacoemusification and unfolded iutraoculavr lens (IOL) implantation through a 6 mm sutureless incision. METHODS A 6 mm sclera tunnel incision was made at 12 o'clock tangent of the posterior limbus and unfolded polymethylmethacrylate(PMMA) IOL implantation was operated in 50 cases (55 eyes); 53 eyes were(More)