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AbstractThe characterization of distributed n-tier application performance is an important and challenging problem due to their complex structure and the significant variations in their workload. Theoretical models have difficulties with such wide range of environmental and workload settings. Experimental approaches using manual scripts are error-prone,(More)
PCR-based identification of differences between two unknown genomes often requires complex manipulation of the templates prior to amplification and/or gel electrophoretic separation of a large number of samples with manual methods. Here, we describe a new genotyping method, called fluorescent motif enhanced polymorphism (fluoMEP). The fluoMEP method is(More)
Colorectal cancer is currently the third in cancer incidence worldwide and the fourth most common cause of cancer deaths. Mortality in colorectal cancer is often ascribed to liver metastasis. In an effort to elucidate the proteins involved in colorectal cancer liver metastasis, we compared the proteome profiles of the human colon adenocarcinoma cell line(More)
The high mortality rate in colorectal cancer is mostly ascribed to metastasis, but the only clinical biomarker available for disease monitoring and prognosis is the carcinoembryonic antigen (CEA). However, the prognostic utility of CEA remains controversial. In an effort to identify novel biomarkers that could be potentially translated for clinical use, we(More)
Cancer is among the most prevalent and serious health problems worldwide. Therefore, there is an urgent need for novel cancer biomarkers with high sensitivity and specificity for early detection and management of the disease. The cancer secretome, encompassing all the proteins that are secreted by cancer cells, is a promising source of biomarkers as the(More)
An Efficient Genetic Algorithm(EGA) proposed in this paper was aiming to high-dimensional function optimization. To generate multiple diverse solutions and to strengthen local search ability, the new subspace crossover and timely mutation operators improved by us will be used in EGA. The combination of the new operators allow the integration of(More)
Information integration, interoperability and adaptation to evolving data are the key components of clinical information system with high potential impact. Most existing systems accomplish integration and interoperability by employing specific data model standards with static mapping rules that makes system inflexible and inextensible. In response to this(More)
In recent years, traditional computing systems face the problems of scalability as the need for information processing services is ever increasing. Grid, as a pool of computing resources, solves the problem in some degree by providing an integrated computing and resources environment. Thus, there emerge many strategies related to grid resource allocation(More)
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