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Monkeys serve as important model species for studying human diseases and developing therapeutic strategies, yet the application of monkeys in biomedical researches has been significantly hindered by the difficulties in producing animals genetically modified at the desired target sites. Here, we first applied the CRISPR/Cas9 system, a versatile tool for(More)
In this paper, global asymptotic stability in probability (GASiP) and stochastic input-to-state stability (SISS) for nonswitched stochastic nonlinear (nSSNL) systems and switched stochastic nonlinear (SSNL) systems are investigated. For the study of GASiP, the definition which we considered is not the usual notion of asymptotic stability in probability(More)
With the rapid growth of Web services in recent years, the optimal service selection from functionally-equivalent service candidates has become more critical for building high quality service-oriented systems. To provide accurate QoSvalues for service selection, user-side QoS prediction thus becomes an important research problem. Although collaborative(More)
The miR-200 family is well known to inhibit the epithelial-mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports regarding the role of miR-200 in suppressing or promoting metastasis in different cancer types have left unanswered questions. Here we demonstrate a difference in clinical outcome based(More)
Recent advances in gene editing technology have introduced the potential for application of mutagenesis approaches in nonhuman primates to model human development and disease. Here we report successful TALEN-mediated mutagenesis of an X-linked, Rett syndrome (RTT) gene, methyl-CpG binding protein 2 (MECP2), in both rhesus and cynomolgus monkeys.(More)
The rising popularity of service-oriented architecture to construct versatile distributed systems makes Web service recommendation and composition a hot research topic. It's a challenge to design accurate personalized QoS prediction approaches for Web service recommendation due to the unpredictable Internet environment and the sparsity of available(More)
This work focuses on the dynamic properties and energetics of the protein/peptide drug during its transport through carbon nanotubes (CNTs). A systematic study was performed on the interaction between the peptide and the CNTs. In the molecular dynamics (MD) simulations, the protein/peptide molecule Zadaxin is observed to be encapsulated inside the nanotube(More)
BACKGROUND We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the mechanisms are not well understood. METHODS We characterized the biologic response of taxane-resistant and taxane-sensitive ovarian cancer models to a novel FAK inhibitor (VS-6063). We used reverse-phase protein arrays (RPPA) to(More)
CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the targeted gene or cause the pathology seen in human disease. Addressing these issues is necessary if we are to(More)
CONTEXT Although recent animal studies have suggested that C1q/TNF-related protein-9 (CTRP9) is more likely to be involved in the regulation of vascular function, more specifically atherosclerosis, in rodents, little is known about whether serum CTRP9 level is associated with atherosclerosis in humans. OBJECTIVE The aim of this study was to investigate(More)