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A simple, accurate, precise, specific and reproducible high-performance liquid chromatography (HPLC) method was developed for simultaneous determination of resveratrol isomers in rat plasma. Cis-resveratrol was made by exposure of a trans-resveratrol solution to sunlight for 5 days followed by separation by HPLC and identification by mass spectrometry (MS).(More)
Alpha-naphthyl isothiocyanate (ANIT) is a known hepatotoxicant that causes acute cholestatic hepatitis characterized by the infiltration of neutrophils around bile ducts and necrotic hepatocytes. The effects of glycyrrhizin (GL), 18beta-glycyrrhetinic acid (GA), matrine (MT), oxymatrine (OMT), salvianolic acid B (SAB), silymarin (SI) and dexamethasone (DEX)(More)
—In this letter, we propose a distance-based ordered detection (DBD) algorithm for spatial modulation (SM) to reduce the receiver complexity and achieve a near maximum likelihood (ML) performance. The proposed algorithm firstly compensates the channel attenuation and obtains the estimated symbols with transmit antenna indices, then orders the indices based(More)
Cyclosporin A (CsA) is a P-glycoprotein (P-gp) inhibitor clinically used as an immunosuppressant. Itraconazole (ITZ) functions as an inhibitor of both the P-gp and CYP3A and is used as a fungistatic/fungicidal agent in human and veterinary medicine. The present studies were designed to investigate the effects of CsA and ITZ on 1) intestinal permeability of(More)
A simple, specific, and precise liquid chromatographic-electrospray ionization mass spectrometric (LC-ESI-MS) method has been developed for determination of nimodipine concentration in human plasma. The method involves the addition of 200 microL of saturated sodium bicarbonate (NaHCO(3)) solution to plasma to improve the extraction recovery, liquid-liquid(More)
To study the metabolites of glycyrrhetic acid (GA) in rat bile, an analytical method was developed to identify GA and its metabolites by liquid chromatography mass spectrometry (LC-MS). Rat bile was collected after i.v. injection of GA. Three major GA-related peaks were detectable in rat bile by high-performance liquid chromatography (HPLC) analysis at 254(More)
A pharmacokinetic study was carried out in rats to investigate the effects of experimental hepatic injury on the liver glucuronidation and bile excretion of ketoprofen (KP) and its glucuronides (KPGs). In vivo, KP (20mg/kg b.w.) was intravenously administered to carbon tetrachloride (CCl(4)) or alpha-naphthylisothiocyanate (ANIT) induced hepatic injury male(More)
Energy efficiency (EE) is one fundamental performance metric for design of orthogonal frequency division multiple access (OFDMA) networks besides spectral efficiency (SE). The conventional resource allocation is to maximize data throughput without consideration of EE. In this paper, we propose a new low-complexity resource allocation algorithm to maximize(More)
AIM To explore the effects of glycyrrhizin (GL) and matrine (MT) on acute vanishing bile duct syndromes (AVBDS) in rats. METHODS AVBDS in rats were induced by alphanaphthylisothiocyanate (ANIT), and the effects of GL and MT on AVBDS were explored and compared with dexamethasone (DEX) by serology determination, histological assessment of liver damage and(More)