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Journals and Conferences
This paper first discusses the background knowledge of the clonal selection algorithm and particle swarm method. The clonal selection algorithm is imitated by the basic principle of the adaptive immune response to virus stimulus. The particle swarm optimization is motivated by the social behaviors of swarms. Inspired by these two optimization methods, we… (More)
Nakiterpiosin and nakiterpiosinone are two related C-nor-D-homosteroids isolated from the sponge Terpios hoshinota that show promise as anticancer agents. We have previously described the asymmetric synthesis and revision of the relative configuration of nakiterpiosin. We now provide detailed information on the stereochemical analysis that supports our… (More)
Synchronization is an important problem in the design and development of the software, which has been resolved in the object-oriented programming (OOP). However, the implementation of OOP is easy to leads to code-tangling and code-scattering between functional properties and crosscutting properties. Aspect-oriented programming (AOP) can solve the problem of… (More)
This manuscript describes a convergent synthesis and the revision of the relative stereochemistry of nakiterpiosin, a marine C-nor-D-homosteroid. Our synthesis features a late-stage carbonylative Stille cross-coupling reaction and a photo-Nazarov cyclization reaction that deliver the complete nakiterpiosin skeleton efficiently.
Two cycloaddition reactions were utilized for the construction of the 5,6,7-tricyclic skeleton of lancifodilactone F and buxapentalactone. A [2+2] ketene cycloaddition reaction was first used to set their adjacent all-carbon quaternary centers at the 5,6-ring junction. An arene-olefin meta-photocycloaddition reaction was then used to install the 6- and… (More)
The Fuzzy C-Means algorithm (FCM) is a widely applied clustering method. However, it is usually trapped into the local optimum. In addition, its performance is very sensi- tive to the initialization. This paper proposes a new fuzzy clustering method based on the immune clonal selection principle, namely CFCM. The clonal selection algorithm is first used to… (More)
Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished… (More)
We report herein the synthesis of a fully functionalized B,C,D-ring system of lancifodilactone F. The key transformations involve an arene-olefin meta-photocycloaddition reaction and a palladium-catalyzed oxidative C-C cleavage reaction to establish its B,C-rings.