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Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single-stranded DNA targets. Though largely specific for immunoglobulin genes, AID also acts on a limited set of(More)
Keywords: Geographical information system Cardinal direction relations Interior direction relations Boundary direction relations Composition of direction relations a b s t r a c t Current models of direction relations are not designed to describe direction information inside the Minimum Bounding Rectangle (MBR) of a reference region. Thus, the direction(More)
The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are(More)
To a significant degree, multimedia applications derive their effectiveness from the use of color graphics, images, and videos. In these applications, human visual system (HVS) often gives the final evaluation of the processed results. In this paper, we first propose a novel color image enhancement method, which is named HVS Controlled Color Image(More)
BACKGROUND Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority. OBJECTIVE We investigated the relationship between inorganic arsenic exposure from drinking water and plasma levels of soluble intercellular adhesion molecule-1(More)
Automatic facial Action Unit (AU) detection from video is a long-standing problem in facial expression analysis. AU detection is typically posed as a classification problem between frames or segments of positive examples and negative ones, where existing work emphasizes the use of different features or classifiers. In this paper, we propose a method called(More)