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T cell Ig domain and mucin domain protein 1 (TIM-1) is a costimulatory molecule that regulates immune responses by modulating CD4+ T cell effector differentiation. However, the function of TIM-1 on other immune cell populations is unknown. Here, we show that in vivo in mice, TIM-1 is predominantly expressed on B rather than T cells. Importantly, TIM-1 was(More)
Amyotrophic lateral sclerosis, or ALS, is a degenerative disease of the motor neurons that eventually leads to complete paralysis. We are developing a wheelchair system that can help ALS patients, and others who can't use physical interfaces such as joysticks or gaze tracking, regain some autonomy. The system must be usable in hospitals and homes with(More)
The involvement of estrogen and its receptors in the development of cancer has been known for years. However, the exact mechanism responsible is far from clear. The estrogen-mediated carcinogenic process is complicated by recent findings, which reveal that estrogens have multiple functions in cells, which can be either adverse or beneficial, and that the(More)
This paper presents the first working prototype of a brain controlled wheelchair able to navigate inside a typical office or hospital environment. This brain controlled wheelchair (BCW) is based on a slow but safe P300 interface. To circumvent the problem caused by the low information rate of the EEG signal, we propose a motion guidance strategy providing(More)
It has not been established which specific measures of obesity might be most appropriate for predicting CVD risk in Asians. The objectives of the present study were to determine the associations of BMI, waist circumference (WC) and waist:height ratio (WHtR) with CVD risk factors and to evaluate the optimal cut-off values to define overweight or obesity in(More)
A high-speed VLSI design of an area-efficient JPEG2000 encoder is given. Recursive multilevel 2D discrete wavelet transform (DWT) architecture with dual buffers is proposed to reduce the wavelet coefficients memory to 1/4 tile size, prerate allocation is used to reduce the compressed code memory to 3/4 tile size. A highly pipelined and parallelism(More)
Maturation of T cell-activating APCs directly links innate and adaptive immunity and is typically triggered by microbial infection. Transplantation of allografts, which are sterile, generates strong T cell responses; however, it is unclear how grafts induce APC maturation in the absence of microbial-derived signals. A widely accepted hypothesis is that(More)
OBJECTIVES Although thyroid cancer occurs much more frequently in females, the role of sex hormones in thyroid carcinogenesis is unknown. In this study, it has been investigated how 17beta-oestradiol (E2) influenced proliferation and growth of thyroid cancer cells. MATERIALS AND METHODS Cell proliferation and its related molecules were examined in thyroid(More)
Fluorine, a toxic and reactive element, is widely prevalent throughout the environment and can induce toxicity when absorbed into the body. This study was to explore the possible mechanisms of developmental neurotoxicity in rats treated with different levels of sodium fluoride (NaF). The rats’ intelligence, as well as changes in neuronal morphology, glucose(More)
BACKGROUND The American Heart Association's 2020 Strategic Goals define a new concept of cardiovascular health. However, the prevalence of ideal cardiovascular health outside of the United States is unclear, and its relationship with psychological status has not been reported. METHOD We included 9962 participants (mean age 47.1 years; 44.2% women) from(More)