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Intracellular detection of RNA virus infection is mediated by the RNA helicase RIG-I, which is recruited to mitochondria by the adaptor protein MAVS and triggers activation of the transcription factors NF-kappaB, IRF3 and IRF7. Here we demonstrate that virus-induced activation of IRF3 and IRF7 depended on the NF-kappaB modulator NEMO, which acted 'upstream'(More)
PURPOSE To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in breast cancer. EXPERIMENTAL DESIGN The expression patterns of miR-195 and miR-497 were initially examined in breast cancer tissues and cell lines by Northern blotting and quantitative real-time PCR. Combined bisulfite restriction analysis and bisulfite(More)
BACKGROUND Delayed afterdepolarizations (DADs) carried by Na(+)-Ca(2+)-exchange current (I(NCX)) in response to sarcoplasmic reticulum (SR) Ca(2+) leak can promote atrial fibrillation (AF). The mechanisms leading to delayed afterdepolarizations in AF patients have not been defined. METHODS AND RESULTS Protein levels (Western blot), membrane currents and(More)
OBJECTIVE To investigate the impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cysts and the possible mechanisms. DESIGN A prospective study. SETTING Obstetrics and Gynecology Department of a university hospital. PATIENT(S) 191 patients with benign ovarian cysts undergoing ovarian cystectomy. INTERVENTION(S)(More)
Serum response factor (SRF) binds a 1216-fold degenerate cis element known as the CArG box. CArG boxes are found primarily in muscle- and growth-factor-associated genes although the full spectrum of functional CArG elements in the genome (the CArGome) has yet to be defined. Here we describe a genome-wide screen to further define the functional mammalian(More)
We evaluated whether real-time ultrasound elastography (USE) performed in addition to conventional ultrasound (US) can improve the differentiation of benign from malignant breast lesions. Both conventional US and real-time USE were performed in 112 consecutive patients with 139 breast lesions using a Hitachi EUB-8500 US system. Each lesion was assigned an(More)
To investigate the feasibility and clinical efficacy of ultrasound (US)-guided diffused optical tomography (DOT) in differentiating malignant breast lesions from benign lesions. From October 2007 to August 2008, 198 women with 214 lesions scheduled for open biopsy were included in this study. Conventional US was used to locate the breast lesion, and DOT to(More)
BACKGROUND Recent studies have shown that C-reactive protein (CRP) may be associated with breast cancer. The purpose of this study is to summarize the predictive role of CRP for survival in breast cancer as shown in all available studies worldwide. METHODS Related studies were identified and evaluated for quality through multiple search strategies. Data(More)
STUDY DESIGN A case-control study is presented. OBJECTIVE To investigate the association of estrogen receptor gene polymorphisms with adolescent idiopathic scoliosis (AIS) risk. SUMMARY OF BACKGROUND DATA Previous studies have shown that genetic factors are important in the pathogenesis of idiopathic scoliosis. Only 1 publication suggested that XbaI(More)