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Cyclophilin A (CyPA) is a ubiquitously distributed peptidylprolyl cis-trans isomerase (PPIase) that possesses diverse biological functions. Extracellular CyPA is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. Although it has been identified that the chemotaxis activity(More)
HAb18G/CD147, a transmembrane glycoprotein highly expressed in various types of malignant cells, mainly functions as an inducer of matrix metalloproteinases to promote tumor growth, invasion and metastasis. However, whether there are other mechanisms underlying the role of HAb18G/CD147 in tumor progression remains to be elucidated. In this study, we(More)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a promising and novel anticancer cytokine, specifically kills numerous tumor cells by apoptosis. However, some malignancies are resistant to TRAIL treatment in clinical trials, thus limiting its therapeutic potential. In the present study, the TRAIL-resistant murine hepatocellular carcinoma(More)
CD147 is a widely expressed transmembrane protein that mediates signal transduction, and it plays important roles in many physiological and pathological processes, such as tumor invasion and metastasis. The extracellular portion of CD147 (CD147(EC)) is responsible for its functional interactions with different signaling molecules. Due to the existence of(More)
In this paper, we study the global existence and nonexistence of positive solutions to the following nonlinear reaction-diffusion system  ut −∆u = W (x)v + S(x) in M × (0,∞), vt −∆v = F (x)u + G(x) in M × (0,∞), u(x, 0) = u0(x) in M, v(x, 0) = v0(x) in M, where M (n ≥ 3) is a non-compact complete Riemannian manifold, ∆ is the Laplace-Beltrami(More)
where M is a compact complete Riemannian manifold, λ is a positive real parameter, and φ 0 (x) : M → R is a smooth function. We show a meaningful precisely asymptotic result which is more general than those in [1]. Monge-Ampère equations arise naturally from some problems in differential geometry. The existence and regularity of solutions to Monge-Ampère(More)
Hollow porous NiCo2O4-nanoboxes (NCO-NBs) were synthesized with zeolitic imidazolate framework-67 (ZIF-67) nanocrystals as the template followed by a subsequent annealing treatment. The structure and morphology of the NCO-NBs were characterized using X-ray diffraction, field emission scanning electron microscopy and transmission electron microscopy. When(More)
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