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The interaction of alpha-dystroglycan (a-DG) with its extracellular binding partners requires glycans attached to its mucin core domain, and defects in the glycosylation of a-DG are associated with both muscular dystrophy and neuronal migration defects. The involvement of a-DG and one of its ligands, agrin, in cerebellar neuronal migration was investigated.(More)
The web is increasingly being used by mobile users. In addition , it is increasingly becoming possible to accurately geo-position mobile users and web content. This development gives prominence to spatial web data management. Specifically, a spatial keyword query takes a user location and user-supplied keywords as arguments and returns web objects that are(More)
With ever-growing popularity of social networks, web and bio-networks, mining large frequent patterns from a single huge network has become increasingly important. Yet the existing pattern mining methods cannot offer the efficiency desirable for large pattern discovery. We propose Spider-Mine, a novel algorithm to efficiently mine top-K largest frequent(More)
We propose a framework for efficient OLAP on information networks with a focus on the most interesting kind, the topological OLAP (called " T-OLAP "), which incurs topological changes in the underlying networks. T-OLAP operations generate new networks from the original ones by rolling up a subset of nodes chosen by certain constraint criteria. The key(More)
BACKGROUND Glioblastoma is the most common type of primary brain tumors. Cisplatin is a commonly used chemotherapeutic agent for Glioblastoma patients. Despite a consistent rate of initial responses, cisplatin treatment often develops chemoresistance, leading to therapeutic failure. Cellular resistance to cisplatin is of great concern and understanding the(More)
The widespread use of social networks enables the rapid diffusion of information, e.g., news, among users in very large communities. It is a substantial challenge to be able to observe and understand such diffusion processes, which may be modeled as networks that are both large and dynamic. A key tool in this regard is data summarization. However, few(More)
Despite the wealth of research on frequent graph pattern mining, how to efficiently mine the complete set of those with constraints still poses a huge challenge to the existing algorithms mainly due to the inherent bottleneck in the mining paradigm. In essence, mining requests with explicitly-specified constraints cannot be handled in a way that is direct(More)
  • Maija P Valta, Teuvo Hentunen, Qiang Qu, Eeva M Valve, Anna Harjula, Jani A Seppänen +2 others
  • 2006
Several members of the fibroblast growth factor (FGF) family have an important role in the development of skeletal tissues. FGF-8 is widely expressed in the developing skeleton, but its function there has remained unknown. We asked in this study whether FGF-8 could have a role in the differentiation of mesenchymal stem cells to an osteoblastic lineage.(More)