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We propose a framework for efficient OLAP on information networks with a focus on the most interesting kind, the topological OLAP (called " T-OLAP "), which incurs topological changes in the underlying networks. T-OLAP operations generate new networks from the original ones by rolling up a subset of nodes chosen by certain constraint criteria. The key(More)
The interaction of alpha-dystroglycan (a-DG) with its extracellular binding partners requires glycans attached to its mucin core domain, and defects in the glycosylation of a-DG are associated with both muscular dystrophy and neuronal migration defects. The involvement of a-DG and one of its ligands, agrin, in cerebellar neuronal migration was investigated.(More)
The web is increasingly being used by mobile users. In addition , it is increasingly becoming possible to accurately geo-position mobile users and web content. This development gives prominence to spatial web data management. Specifically, a spatial keyword query takes a user location and user-supplied keywords as arguments and returns web objects that are(More)
With ever-growing popularity of social networks, web and bio-networks, mining large frequent patterns from a single huge network has become increasingly important. Yet the existing pattern mining methods cannot offer the efficiency desirable for large pattern discovery. We propose Spider-Mine, a novel algorithm to efficiently mine top-K largest frequent(More)
The widespread use of social networks enables the rapid diffusion of information, e.g., news, among users in very large communities. It is a substantial challenge to be able to observe and understand such diffusion processes, which may be modeled as networks that are both large and dynamic. A key tool in this regard is data summarization. However, few(More)
Despite the wealth of research on frequent graph pattern mining, how to efficiently mine the complete set of those with constraints still poses a huge challenge to the existing algorithms mainly due to the inherent bottleneck in the mining paradigm. In essence, mining requests with explicitly-specified constraints cannot be handled in a way that is direct(More)
Dystroglycan (DG) plays a central role in linking the extracellular matrix to cellular cytoskeletal elements, and is required for proper neuromuscular junction organization and neural cell migration in the CNS. DG interactions with laminin and several other extracellular ligands are mediated through carbohydrates located in a densely glycosylated mucin core(More)
Cerebellar granule neurons (CGNs) undergo a well-defined, intrinsic differentiation program that is recapitulated in vitro. Thus, homogeneous cultures of CGNs provide an excellent opportunity to define the mechanisms underlying their development. The ability to alter endogenous gene expression in CGNs on a population-wide basis would greatly facilitate the(More)