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BACKGROUND MicroRNAs (miRNAs) are a class of small non-coding RNAs to regulate cell differentiation, proliferation, development, and apoptosis. The single nucleotide polymorphism (SNP) rs895819 is located at the terminal loop of pre-miR-27a. Here, we aimed to investigate whether SNP rs895819 was associated with the development of renal cell cancer (RCC) in(More)
  • Robert H Scannevin, KeWei Wang, Flora Jow, Jennifer Megules, David C Kopsco, Wade Edris +15 others
  • 2004
The family of calcium binding proteins called KChIPs associates with Kv4 family K(+) channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Two regions in the Kv4.2 N terminus, residues 7-11 and 71-90, are necessary for KChIP1 modulation and(More)
Structural profiling of healthy human gut microbiota across heterogeneous populations is necessary for benchmarking and characterizing the potential ecosystem services provided by particular gut symbionts for maintaining the health of their hosts. Here we performed a large structural survey of fecal microbiota in 314 healthy young adults, covering 20 rural(More)
Predicting the three-dimensional structure of proteins from amino acid sequences with only a few remote homologs, or de novo prediction, remains a major challenge in computational biology. The modeling of the protein backbone represents the initial phase of a protein structure prediction process. Using a parallel ant colony optimization based on sharing one(More)
Automatic translation evaluation is popular in development of MT systems, but further research is necessary for better evaluation methods and selection of an appropriate evaluation suite. This paper is an attempt for an in-depth analysis of the performance of MT evaluation methods. Difficulty, discriminability and reliability characteristics are proposed(More)
BACKGROUND Protein structure prediction (PSP), which is usually modeled as a computational optimization problem, remains one of the biggest challenges in computational biology. PSP encounters two difficult obstacles: the inaccurate energy function problem and the searching problem. Even if the lowest energy has been luckily found by the searching procedure,(More)