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  • Qiang Lu, Edna E. Sun, Robyn S. Klein, John G. Flanagan
  • 2001
Transmembrane B ephrins and their Eph receptors signal bidirectionally. However, neither the cell biological effects nor signal transduction mechanisms of the reverse signal are well understood. We describe a cytoplasmic protein, PDZ-RGS3, which binds B ephrins through a PDZ domain, and has a regulator of heterotrimeric G protein signaling (RGS) domain.(More)
  • David A Feldheim, Pierre Vanderhaeghen, Michael J Hansen, Jonas Frisén, Qiang Lu, Mariano Barbacid +1 other
  • 1998
Visual connections to the mammalian forebrain are known to be patterned by neural activity, but it remains unknown whether the map topography of such higher sensory projections depends on axon guidance labels. Here, we show complementary expression and binding for the receptor EphA5 in mouse retina and its ligands ephrin-A2 and ephrin-A5 in multiple retinal(More)
Characterization of neural promoter/enhancers is essential for understanding gene regulation during brain development and provides useful genetic tools. However, it relies on the use of transgenic mice. We report a method for the rapid in vivo analysis of neural promoter/enhancers in the developing mouse brain and its application in the isolation of the(More)
As axons grow past intermediate targets, they change their responsiveness to guidance cues. Local upregulation of receptor expression is involved, but the mechanisms for this are not clear. Here protein synthesis is traced within individual axons by introducing RNAs encoding visualizable reporters. Individual severed axons and growth cones can translate(More)
In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young(More)
—In this paper, a multimachine power system is first represented as the generalized Hamiltonian control system with dissipation. Then, a decentralized saturated steam valving and ex-citation controller, which is staticly measurable, is proposed based on the Hamiltonian function method. Last, an example of three-machine power system is discussed in detail.
Search is a major technique for planning. It amounts to exploring a state space of planning domains typically modeled as a directed graph. However, prohibitively large sizes of the search space make search expensive. Developing better heuristic functions has been the main technique for improving search efficiency. Nevertheless, recent studies have shown(More)
Complex features, such as temporal dependencies and numerical cost constraints, are hallmarks of real-world planning problems. In this article, we consider the challenging problem of cost-sensitive temporally expressive (CSTE) planning, which requires concurrency of durative actions and optimization of action costs. We first propose a scheme to translate a(More)
—System splitting problem (SS problem) is to determine proper splitting points (or called splitting strategies) to split the entire interconnected transmission network into islands ensuring generation/load balance and satisfaction of transmission capacity constraints when islanding operation of system is unavoidable. For a large-scale power system, its SS(More)