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Fuzzy local linearization is compared with local basis function expansion for modeling unknown nonlinear processes. First-order Takagi-Sugeno fuzzy model and the analysis of variance (ANOVA) decomposition are combined for the fuzzy local linearization of nonlinear systems, in which B-splines are used as membership functions of the fuzzy sets for input space(More)
BACKGROUND Increasing evidence demonstrates that stem cells maintain their identities by a unique transcription network and chromatin structure. Opposing epigenetic modifications H3K27 me3 and H3K4 me3 have been proposed to label differentiation-associated genes in stem cells, progenitor and precursor cells. In addition, many differentiation-associated(More)
Fuzzy local linearization (FLL) is a useful divide-and-conquer method for coping with complex problems such as modeling unknown nonlinear systems from data for state estimation and control. Based on a probabilistic interpretation of FLL, the paper proposes a hybrid learning scheme for FLL modeling, which uses a modified adaptive spline modeling (MASMOD)(More)
Numerous studies have implicated the cAMP-protein kinase A (PKA) pathway in producing hyperexcitability of dorsal root ganglia (DRG) sensory neurons under conditions associated with pain. Evidence is presented for roles of both the cAMP-PKA and cGMP-protein kinase G (PKG) pathways in maintaining neuronal hyperexcitability and behavioral hyperalgesia in a(More)
Many studies have demonstrated that SIRT1, an NAD+-dependent deacetylase, reduces apoptosis in several different cells. However, the role of SIRT1 in apoptosis of disc nucleus pulposus (NP) cells remains unclear. The present study was performed to determine whether degenerative human NP would express SIRT1, and to investigate the role of SIRT1 in NP cells(More)
Neuropathic pain after nerve injury is severe and intractable, and current drugs and nondrug therapies offer substantial pain relief to no more than half of affected patients. The present study investigated the analgesic roles of the B vitamins thiamine (B1), pyridoxine (B6) and cyanocobalamin (B12) in rats with neuropathic pain caused by spinal ganglia(More)