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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.
It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- T. Ikenoue, K. Inoki, Qian Yang, Xiaoming Zhou, K. Guan
- Biology, ChemistryThe EMBO journal
- 23 July 2008
It is shown that the mammalian target of rapamycin complex 2 (mTORC2) has an important function in phosphorylation of both TM and HM in all conventional PKCs, novel PKCε as well as Akt.
Expanding mTOR signaling
Different mTOR-associated proteins, the regulation of mTOR complexes, and the consequences of m TOR dysregulation under pathophysiological conditions are discussed.
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
It is reported that Sin1 is an essential component of mTORC2 but not ofTORC1, and functions similarly to Rictor, the defining member of TORC2, in complex formation and kinase activity, and plays an essential role in Akt phosphorylation and signaling.
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
A search for substrates of a growth-promoting kinase revealed a regulatory feedback loop involved in tumor suppression, and large-scale quantitative phosphoproteomics experiments were used to define the signaling networks downstream of mTORC1 and m TORC2.
Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
It is found that chaperone-mediated autophagy regulated the activity of myocyte enhancer factor 2D (MEF2D), a transcription factor required for neuronal survival, and dysregulation of this pathway is associated with Parkinson's disease.
Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid.
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
- Qian Yang, K. Inoki, Eunjung Kim, K. Guan
- BiologyProceedings of the National Academy of Sciences…
- 2 May 2006
It is reported that dRheb has an inhibitory effect on dTORC2 activity in Drosophila S2 cells, and observations suggest that TSC1/2 and Rheb have different effects on the activity of TORC1 and -2, further supporting the complexity of TOR regulation.
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice.
- Insook Kim, K. Morimura, Y. Shah, Qian Yang, J. Ward, F. Gonzalez
- Biology, MedicineCarcinogenesis
- 1 May 2007
A potential role for FXR and BAs in hepatocarcinogenesis is revealed and increased cell proliferation is revealed as revealed by increased PCNA mRNA and BrdU incorporation.