• Publications
  • Influence
Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and
TLDR
The results showed that circRNA_100284 is involved in the malignant transformation of L-02 cells induced by arsenite, and the concept that exosomal circRNAs are involved in cell–cell communication during carcinogenesis induced by arsenalite is supported. Expand
MicroRNA-218 acts by repressing TNFR1-mediated activation of NF-κB, which is involved in MUC5AC hyper-production and inflammation in smoking-induced bronchiolitis of COPD.
TLDR
A mechanism by which miR-218 regulates CSE-induced MUC5AC hyper-production and inflammation by targeting TNFR1-mediated activation of NF-κB is provided, indicating that overexpression of miR -218 may be a strategy against cigarette smoking-induced bronchiolitis in COPD. Expand
Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking
TLDR
It is demonstrated that CS triggers the modification of exosome components and miR-21 derived from bronchial epithelial cells as a mediator of myofibroblast differentiation through the pVHL/HIF-1α signaling pathway, which has potential value for diagnosis and treatment of COPD. Expand
Exosomal MALAT1 Derived from Hepatic Cells is Involved in The Activation of Hepatic Stellate Cells via miRNA-26b in Fibrosis Induced by Arsenite.
TLDR
Exosomes derived from arsenite-treated hepatic cells transferred MALAT1 to HSCs, which induced their activation, and these findings support the concept that, during liver fibrosis induced by arsenite, exosomal lncRNAs are involved in cell-cell communication. Expand
Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR.
TLDR
It is established that, in HBE cells, andrographolide reversed the CSE-induced EMT via decreasing IL-6 levels and, in an animal model, prevented CS-induced lung inflammation and small airway remodeling, indicating that it has potential clinical application for CS- induced pulmonary dysfunction and COPD. Expand
MALAT1 via microRNA‐17 regulation of insulin transcription is involved in the dysfunction of pancreatic β‐cells induced by cigarette smoke extract
TLDR
CSE inhibits insulin production by upregulating TXNIP via MALAT1‐mediated downregulation of miR‐17, which provides an understanding of the processes involved in the reduced β‐cells function caused by cigarette smoke. Expand
Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis.
TLDR
In HaCaT cells, arsenite decreases circ008913 levels, which act as a sponge for miR-889 and down-regulate the miR -889 target, DAB2IP, which, in turn, up-regulates ZEB1, increases mRNA levels of the cell-surface markers of skin stem cells, and is involved in arsenite-induced acquisition of CSC-like properties that lead to malignant transformation. Expand
Wnt/β-Catenin Pathway Is Involved in Cadmium-Induced Inhibition of Osteoblast Differentiation of Bone Marrow Mesenchymal Stem Cells
TLDR
The current research shows that CdCl2 suppresses the osteogenesis of BMMSCs via inhibiting the Wnt/β-catenin pathway, establishing a previously unknown mechanism for bone injury induced by Cd Cl2. Expand
CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes
TLDR
For HaCaT cells chronically exposed to arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT during malignant transformation, establishing a previously unknown mechanism for arsenite-induced carcinogenesis. Expand
Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1β from human hepatic cells.
TLDR
By elevating the secretion of IL-1β, miR-379-5p regulation of GSDMD is involved in arsenite-induced activation of HSCs and in hepatic fibrosis, which establishes a previously unknown molecular mechanism for arsenic-induced liver damage, inflammation, and fibrosis. Expand
...
1
2
...