Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol
- Qian S Zhang, B. Browning, S. Browning
- Biology, MedicineEuropean Journal of Human Genetics
- 1 May 2015
Haplotype clusters in the chromosome 4q13.3-q21.1 region containing the albumin (ALB) and platelet factor 4 (PF4) genes were associated with LDL, illustrating the power of haplotypic association testing.
Genome-wide association study of heart rate and its variability in Hispanic/Latino cohorts.
- K. Kerr, C. Avery, E. Whitsel
- Medicine, BiologyHeart Rhythm
- 1 November 2017
ASAFE: ancestry-specific allele frequency estimation
- Qian S Zhang, B. Browning, S. Browning
- BiologyBioinform.
- 15 July 2016
An EM algorithm is derived to estimate ancestry-specific allele frequencies for a bi-allelic marker given genotypes and local ancestries on a 3-way admixed population, when the phase of each admixed individual's genotype relative to the pair ofLocal ancestries is unknown.
Rank-invariant estimation of inbreeding coefficients
- Qian S Zhang, J. Goudet, B. Weir
- MathematicsHeredity
- 25 November 2021
How allele sharing estimates are the relevant quantities for a range of empirical applications is discussed and the variation in rankings for common estimators applied to different subdivisions of 1000 Genomes data is shown.