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Coupling of the nucleus and cytoplasm
TLDR
Data from this study support a model in which Sun proteins tether nesprins in the ONM via interactions spanning the PNS, and form a complex that links the nucleoskeleton and cytoskeleton (the LINC complex). Expand
CB2 cannabinoid receptor-mediated peripheral antinociception
TLDR
Using AM1241, a CB2 receptor‐selective agonist, it is demonstrated that CB2 receptors produce antinociception to thermal stimuli and the local, peripheral nature of CB2 cannabinoid antinOCiception is demonstrated. Expand
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization
TLDR
A search for proteins displaying a conserved C-terminal sequence present in nesprins 1–3 identified Nesp4, a new member of this family that is a kinesin-1-binding protein that displays Sun-dependent localization to the ONM. Expand
A high-throughput method to monitor the expression of microRNA precursors.
TLDR
A sensitive, high throughput, real-time PCR assay to monitor the expression of miRNA precursors and proposes that the PCR assay may be scaled up to include all of the 150+ known human miRNA genes and can easily be adaptable to other organisms such as plants, Caenorhabditis elegans and Drosophila. Expand
Biosynthesis of poly(3-hydroxydecanoate) and 3-hydroxydodecanoate dominating polyhydroxyalkanoates by β-oxidation pathway inhibited Pseudomonas putida.
TLDR
For the first time, it was shown that homopolymer PHD and 3HDD monomers dominating PHA could be synthesized by β-oxidation inhibiting P. putida grown on relevant carbon sources. Expand
RTE1 Is a Golgi-Associated and ETR1-Dependent Negative Regulator of Ethylene Responses1[C][W]
TLDR
The results suggest specificity of the RTE1 function to ETR1 and that endomembranes may play a role in the ethylene signal transduction. Expand
B Cells Have Distinct Roles in Host Protection against Different Nematode Parasites
B cells can mediate protective responses against nematode parasites by supporting Th2 cell development and/or by producing Abs. To examine this, B cell-deficient mice were inoculated withExpand
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
TLDR
It is demonstrated that GDNF-family receptor α-like (GFRAL), an orphan member of the GFR-α family, is a high-affinity receptor for GDF15 that mediates the metabolic effects of GDF12 and binds to GDF 15 in vitro and is required for the metabolic actions of G DF15 with respect to body weight and food intake in vivo in mice. Expand
Receptor Signal Output Mediated by the ETR1 N Terminus Is Primarily Subfamily I Receptor Dependent1[W]
TLDR
It is shown that both etr1(1-349) and etr2-1 (1- 349) are capable of receptor signal output, which is primarily dependent on subfamily I receptors, and possible roles of sub family I receptors and disulfide linkages in ETR1 receptors signal output mediated through the N terminus are discussed. Expand
Plant phenomics and high-throughput phenotyping: accelerating rice functional genomics using multidisciplinary technologies.
TLDR
The key plant phenotyping technologies, particularly photonics-based technologies, are discussed, and their current applications in rice (wheat or barley) phenomics are introduced and are confident that these reliable high-throughput phenotypesing tools will give plant scientists new perspectives on the information encoded in the rice genome. Expand
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