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PURPOSE This study was designed to compare robot-assisted gastrectomy with laparoscopy-assisted gastrectomy in surgical performance and short-term clinical outcomes for gastric cancer and evaluate the safety and feasibility of robotic surgery. METHODS A retrospective database of patients who underwent robotic or laparoscopic gastrectomy for gastric cancer(More)
Simulation and comparison of the routing protocols for network topology hold a significant position in the performance evaluation of wireless networks. This paper aims to experimentally compare and analyze the performance of four wireless network protocols in ad hoc network: AODV, DSR, DSDV, and OLSR. In the experiments, these protocols are simulated using(More)
As product-line engineering becomes more widespread, more safety-critical software product lines are being built. This paper describes a structured method for performing safety analysis on a software product line, building on standard product-line assets: product-line requirements, architecture, and scenarios. The safety-analysis method is bi-directional in(More)
To improve the security awareness of end users, Android markets directly present two classes of literal app information: 1) permission requests and 2) textual descriptions. Unfortunately, neither can serve the needs. A permission list is not only hard to understand but also inadequate; textual descriptions provided by developers are not security-centric and(More)
The family Picornaviridae comprises of small, non-enveloped, positive-strand RNA viruses and contains many human and animal pathogens including enteroviruses (e.g. poliovirus, coxsackievirus, enterovirus 71 and rhinovirus), cardioviruses (e.g. encephalomyocarditis virus), hepatitis A virus and foot-and-mouth disease virus. Picornavirus infections activate a(More)
Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with human hepatocytes has shown promise, these models are subject(More)
BACKGROUND Flavopiridol (FLAP) is a promising chemotherapeutic agent undergoing clinical phase I and phase II trials, and a number of studies have elucidated its hepatic metabolism and biliary disposition. METHODS In present study, the intestinal disposition of orally administered FLAP was characterized through pharmacokinetic studies in rats as well as(More)
A rapid, specific and sensitive method was developed for the simultaneous determination of eight Aconitum alkaloids: aconitine (AC), mesaconitine (MA), hypaconitine (HA), benzoylaconine (BAC), benzoylmesaconine (BMA), benzoylhypaconine (BHA), aconine and mesaconine in rat blood by ultra-performance liquid chromatography coupled tandem mass spectrometry(More)
Emodin is a poorly bioavailable but promising plant-derived anticancer drug candidate. The low oral bioavailability of emodin is due to its extensive glucuronidation in the intestine and liver. Caco-2 cell culture model was used to investigate the interplay between UDP-glucuronosyltransferases (UGTs) and efflux transporters in the intestinal disposition of(More)
Replication of many RNA viruses is accompanied by extensive remodeling of intracellular membranes. In poliovirus-infected cells, ER and Golgi stacks disappear, while new clusters of vesicle-like structures form sites for viral RNA synthesis. Virus replication is inhibited by brefeldin A (BFA), implicating some components(s) of the cellular secretory pathway(More)