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PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells
TLDR
It is suggested that the PI3K/Akt pathway might play a key role in bufalin-induced apoptosis in gastric cancer MGC803 cells. Expand
The QUAZAR AML-001 Maintenance Trial: Results of a Phase III International, Randomized, Double-Blind, Placebo-Controlled Study of CC-486 (Oral Formulation of Azacitidine) in Patients with Acute
Introduction: Many older patients (pts) with AML respond to intensive induction chemotherapy (IC), but responses are often short-lived and overall survival (OS) is poor. The benefit of post-remissionExpand
Circulating microRNA expressions in colorectal cancer as predictors of response to chemotherapy
TLDR
A group of miRNA predictors in response to chemosensitivity for CRC patients are identified, which could lead to a significant improvement in chemotherapy regimen selection strategy and personalized CRC management. Expand
Pharmacokinetics of different formulations of oral azacitidine (CC‐486) and the effect of food and modified gastric pH on pharmacokinetics in subjects with hematologic malignancies
TLDR
Oral azacitidine is rapidly absorbed with little or no effect of food on PK parameters, and does not require dose adjustments when taking a proton‐pump inhibitor. Expand
Elevated serum CA19-9 level is a promising predictor for poor prognosis in patients with resectable pancreatic ductal adenocarcinoma: a pilot study
TLDR
The preoperative elevated CA19-9 level is a promising independent factor for predicting a poor prognosis in PDAC, and the optimal cutoff value is 338.45 U/mL. Expand
Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission.
TLDR
CC-486 maintenance therapy was associated with significantly longer overall and relapse-free survival than placebo among older patients with AML who were in remission after chemotherapy. Expand
CC-486 (Oral Azacitidine) Monotherapy in Patients with Acute Myeloid Leukemia (AML)
TLDR
Evaluate the safety and efficacy of CC-486 administered in extended dosing schedules (14 days or 21 days per 28-day cycle) in patients with AML and found generally comparable responses and response rates across the 4 dosing regimens. Expand
Serum calcium level used as a prognostic predictor in patients with resectable pancreatic ductal adenocarcinoma.
TLDR
The higher serum calcium level is associated with poor prognosis in patients with resectable PDAC and the level of serum calcium can predict death within one year after surgery. Expand
Tamoxifen reverses epithelial–mesenchymal transition by demethylating miR-200c in triple-negative breast cancer cells
  • Qian Wang, Yu Cheng, +9 authors Yunpeng Liu
  • Medicine
  • BMC Cancer
  • 19 July 2017
TLDR
The results indicate that TAM inhibits cell migration and enhances chemosensitivity of mesenchymal TNBC cells by reversing their EMT-like property; and that this E MT-reversal effect results from upregulation of miR-200c through demethylating its promoter. Expand
How to differentiate pseudoprogression from true progression in cancer patients treated with immunotherapy.
TLDR
This work summarized the available data on methods to differentiate pseudoprogression from true progression in patients who have been treated with immunotherapy including biomarkers, medical imaging techniques and biopsy and introduces hyperprogression and special pseudiprogression for improved evaluation of immunotherapy. Expand
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