Qi-cong Zhu

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l-dopa-l-Tyr was synthesized by Fmoc solid-phase peptide synthesis, purified by reversed-phase HPLC and characterized by using 1H, 13C NMR and ESI–MS analyses. The interaction of l-dopa-l-Tyr and l-dopa with ctDNA has been investigated respectively by UV–vis absorption and fluorescence spectroscopy. The results showed that both l-dopa and l-dopa-l-Tyr(More)
BACKGROUND & OBJECTIVE Docetaxel extravasating into the surrounding tissues may lead to severe skin damage. No guideline for handling docetaxel extravasation has been proposed till now. This study was to explore the efficacy of chitosan and hyaluronidase on skin damage caused by docetaxel extravasation in a rat model. METHODS A docetaxel extravasation(More)
OBJECTIVE To evaluate the effects of topical DMSO and intralesional hyaluronidase administration, used alone or in combination, on skin injury due to vinorelbine extravasation in rats. METHODS Skin injury due to vinorelbine extravasation was induced in the lower extremities of 30 SD rats, which were treated subsequently with topical DMSO, intralesional(More)
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