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The F-box protein CORONATINE INSENSITIVE1 (COI1) plays a central role in jasmonate (JA) signaling and is required for all JA responses in Arabidopsis (Arabidopsis thaliana). To dissect JA signal transduction, we isolated the partially suppressing coi1 (psc1) mutant, which partially suppressed coi1 insensitivity to JA inhibition of root growth. The psc1(More)
Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation between two face-selective regions in human brain, the(More)
The domestic pig is of enormous agricultural significance and valuable models for many human diseases. Information concerning the pig microRNAome (miRNAome) has been long overdue and elucidation of this information will permit an atlas of microRNA (miRNA) regulation functions and networks to be constructed. Here we performed a comprehensive search for(More)
BACKGROUND The Michigan Maternal and Infant Health Program (MIHP) is a population-based home-visitation program providing care coordination, referrals, and visits based on a plan of care. MIHP is available to all Medicaid-eligible pregnant women and infants aged ≤1 year in Michigan. PURPOSE To assess the effects of MIHP participation on maternal and(More)
PURPOSE To investigate (1) the mechanism of blood-retinal barrier breakdown induced by protein kinase C (PKC) activation (2) the relationship between PKC activation and vascular endothelial growth factor (VEGF) in 2-week streptozotocin-induced diabetes. METHODS Retinal PKC activities, retinal and vitreous concentration of VEGF protein were conducted by(More)
PURPOSE To investigate the vitreous levels of bevacizumab and vascular endothelial growth factor-A (VEGF-A) after intravitreal injection of the drug in patients with choroidal neovascularization (CNV). DESIGN Interventional case series. PARTICIPANTS Eleven eyes of 11 patients with submacular hemorrhage and CNV due to age-related macular degeneration (n(More)
What makes one person socially insightful but mathematically challenged, and another musically gifted yet devoid of a sense of direction? Individual differences in general cognitive ability are thought to be mediated by "generalist genes" that affect many cognitive abilities similarly without specific genetic influences on particular cognitive abilities(More)
The complexity and physical distribution of modern active-safety automotive applications requires the use of distributed architectures. These architectures consist of multiple electronic control units (ECUs) connected with standardized buses. The most common configuration features periodic activation of tasks and messages coupled with run-time(More)
— The platform-based design methodology [1] is based on the usage of formal modeling techniques, clearly defined abstraction levels and the separation of concerns to enable an effective design process. The METROPOLIS framework embodies the platform-based design methodology and has been applied to a number of case studies across multiple domains. Based on(More)