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Four Chewings fescue and two strong creeping red fescue selections that had been artificially inoculated and stably maintained with four different endophytes were evaluated in feeding trials with chinch bugs (Blissus leucopterus hirtus). Significant differences in survival were found between the endophyte-inoculated plants and their endophyte-free(More)
Endothelial dysfunction underlies the pathogenesis of preeclampsia, but its mechanism has not yet been completely understood. In this study we have aimed to measure homocysteine (Hcy), asymmetric dimethylarginine (ADMA), and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Control–case study with 62 preeclamptic patients(More)
UNLABELLED Background- We hypothesized that molecular imaging of endothelial cell adhesion molecule expression could noninvasively evaluate prelesion atherogenic phenotype. METHODS AND RESULTS Mice deficient for the LDL-receptor and the Apobec-1 editing peptide (DKO mice) were studied as an age-dependent model of atherosclerosis. At 10, 20, and 40 weeks(More)
Forkhead box protein 3 (Foxp3) is known as a specific marker for regulatory T cells which contribute to immunosuppression in tumor microenvironment. However, existing studies regarding clinical significance of Foxp3+ tumor-infiltrating lymphocytes (TILs) in glioblastoma (GBM) remained discrepant. In this study, we aimed to explore whether this subtype of(More)
Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glioma controls (n = 6). TRIM28 expression(More)
BACKGROUND In atherosclerosis, local generation of reactive oxygen species amplifies the inflammatory response and contributes to plaque vulnerability. We used molecular imaging to test whether inhibition of NADPH oxidase with apocynin would reduce endothelial inflammatory activation and endothelial-platelet interactions, thereby interrupting progression to(More)
Physiological/behavioral/perceptual responses to an auditory stimulus can be inhibited by another leading auditory stimulus at certain stimulus intervals, and have been considered useful models of auditory gating processes. Two typical examples of auditory gating are prepulse inhibition of the startle reflex and the precedence effect (echo suppression).(More)
PURPOSE The objective of this study was to evaluate clinical significance and immunosuppressive mechanisms of B7-H4 (B7x/B7S1), a B7 family member, in glioma. EXPERIMENTAL DESIGN B7-H4 levels in glioma tissue/cerebral spinal fluid (CSF) were compared between different grades of glioma patients. Survival data were analyzed with Kaplan-Meier to determine(More)
Most animal vocalizations, including echolocation signals used by bats, contain frequency-modulated (FM) components. Previous studies have described a class of neurons in the inferior colliculus (IC) of the big brown bat that respond exclusively to sinusoidally frequency modulated (SFM) signals and fail to respond to pure tones, noise, amplitude-modulated(More)
Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were(More)