LDL cholesterol (LDL-C) is cleared from plasma via cellular uptake and internalization processes that are largely mediated by the low-density lipoprotein cholesterol receptor (LDL-R). LDL-R is targeted for lysosomal degradation by association with proprotein convertase subtilisin-kexin type 9 (PCSK9). Gain of function mutations in PCSK9 can result in… (More)
Glycoproteins In their Communication on page 13198 ff., Q.-Y. Hu, F. Micoli et al. present two methods for the preparation of glycoconjugate vaccines with one single sugar chain linked to one or two positions of a carrier protein.