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Gene-set analysis evaluates the expression of biological pathways, or a priori defined gene sets, rather than that of individual genes, in association with a binary phenotype, and is of great biologic interest in many DNA microarray studies. Gene Set Enrichment Analysis (GSEA) has been applied widely as a tool for gene-set analyses. We describe here some(More)
Labeled examples are often expensive and time-consuming to obtain. One practically important problem is: can the labeled data from other related sources help predict the target task, even if they have (a) different feature spaces (e.g., image vs. text data), (b) different data distributions, and (c) different output spaces? This paper proposes a solution(More)
In metazoans, cells depend on extracellular growth factors for energy homeostasis. We found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser(86), which directly acetylates and stimulates the protein kinase ULK1, which is required for(More)
Recommender systems suggest a few items from many possible choices to the users by understanding their past behaviors. In these systems, the user behaviors are influenced by the hidden interests of the users. Learning to leverage the information about user interests is often critical for making better recommendations. However, existing(More)
MOTIVATION The increasing availability of complete genome sequences provides excellent opportunity for the further development of tools for functional studies in proteomics. Several experimental approaches and in silico algorithms have been developed to cluster proteins into networks of biological significance that may provide new biological insights,(More)
BACKGROUND Adult survivors of childhood central nervous system (CNS) malignancies are at high risk for long-term morbidity and late mortality. However, patterns of late mortality, the long-term risks of subsequent neoplasms and debilitating medical conditions, and sociodemographic outcomes have not been comprehensively characterized for individual(More)
The information of protein targets and small molecule has been highly valued by biomedical and pharmaceutical research. Several protein target databases are available online for FDA-approved drugs as well as the promising precursors that have largely facilitated the mechanistic study and subsequent research for drug discovery. However, those related(More)
......Godson-3 is the third generation of the Godson microprocessor series, a project of the Institute of Computing Technology at the Chinese Academy of Sciences. As a multicore processor, Godson-3 targets high-throughput server applications, highperformance scientific computing, and high-end embedded applications. Godson-3’s scalable and distributed onchip(More)
Resistive memory (ReRAM) based on a solid-electrolyte insulator is a promising nanoscale device and has great potentials in nonvolatile memory, analog circuits, and neuromorphic applications. The underlying resistive switching (RS) mechanism of ReRAM is suggested to be the formation and rupture of nanoscale conductive filament (CF) inside the(More)