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Establishment of an interleukin-1β-induced inflammation-activated endothelial cell-smooth muscle cell-mononuclear cell co-culture model and evaluation of the anti-inflammatory effects of tanshinone
TLDR
The present study presented a reliable method for the identification of drugs with potential anti-inflammatory activity in atherosclerosis, for investigating the mechanisms of action, considering the improvement of the inflammatory state and the increase in plaque stability observed.
Lonicerae Japonicae Flos and Lonicerae Flos: A Systematic Pharmacology Review
TLDR
Evidence supporting separate listing of Lonicerae japonicae flos and Lonice flos in Chinese Pharmacopeia is provided as well as references for revision of relevant pharmacopeial records dealing with traditional efficacy.
Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo.
TLDR
The flavonoids casticin and chrysosplenol D from A. annua L inhibited inflammation in vitro and in vivo and reduced LPS-induced IκB and c-JUN phosphorylation in Raw264.7 cells.
Artemisinin B Improves Learning and Memory Impairment in AD Dementia Mice by Suppressing Neuroinflammation
TLDR
The results suggested that artemisinin B might inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway, and direct evidence for the potential application of artemis inin B in the treatment of neuroinflammatory diseases is provided.
Cytotoxic biflavones from Stellera chamaejasme.
TLDR
Two new biflavones were isolated from Stellera chamaejasme and sikokianin D was found to possess the most potential cytotoxic activities against both the two cell lines with IC50 values of 1.29 ± 0.21 and 0.25 μM, respectively.
Dihydroartemisinin Regulates the Th/Treg Balance by Inducing Activated CD4+ T cell Apoptosis via Heme Oxygenase-1 Induction in Mouse Models of Inflammatory Bowel Disease
TLDR
DHA is a novel and valuable candidate for IBD therapy or Th/Treg immunoregulation and promoted heme oxygenase-1 (HO-1) production in vitro and in vivo, concomitant with CD4+ T cell apoptosis and restoration of the Th/ Treg balance.
Autophagy regulatory molecule, TMEM74, interacts with BIK and inhibits BIK-induced apoptosis.
TLDR
The results revealed the autophagy modulator TMEM74 interrelates with apoptosis inducer BIK and inhibits its function, which provides a novel crosstalk point between Autophagy and apoptosis to enlarge the understanding of the programmed cell death.
Wuji Wan Formula Ameliorates Diarrhea and Disordered Colonic Motility in Post-inflammation Irritable Bowel Syndrome Rats by Modulating the Gut Microbiota
TLDR
Wuji Wan may remit IBS by modulating the gut microbiota and stabilizing the gut mucosal barrier, indicating that the use of a classical formula of Traditional Chinese Medicine (TCM) that exhibits a prebiotic effect may be a promising strategy for PI-IBS treatment.
Extract of Caulis Spatholobi, a novel blocker targeting tumor cell‑induced platelet aggregation, inhibits breast cancer metastasis.
TLDR
A promising candidate for the interference of breast metastasis by suppressing TCIPA is obtained through drug efficacy identification and pharmacological revealing, which will be beneficial for clinical cancer treatment.
Quality marker identification based on standard decoction of differently processed materials of Ephedrae Herba.
TLDR
This study demonstrates that the standard decoction is a reasonable research objective to explore chemical markers that correlate with the clinical efficacy of TCM.
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