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Devising a complete and correct set of roles has been recognized as one of the most important and challenging tasks in implementing role based access control. A key problem related to this is the notion of goodness/interestingness -- when is a role good/interesting? In this paper, we define the <i>role mining problem</i> (RMP) as the problem of discovering(More)
An improved understanding of the relationship between search intent, result quality, and searcher behavior is crucial for improving the effectiveness of web search. While recent progress in user behavior mining has been largely focused on aggregate server-side click logs, we present a new class of search behavior models that also exploit fine-grained user(More)
Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroendocrine cells of the small intestine. Several GPR40(More)
A better understanding of strategies and behavior of successful searchers is crucial for improving the experience of all searchers. However, research of search behavior has been struggling with the tension between the relatively small-scale, but controlled lab studies, and the large-scale log-based studies where the searcher intent and many other important(More)
Search engine switching is the voluntary transition between Web search engines. Engine switching can occur for a number of reasons, including user dissatisfaction with search results, a desire for broader topic coverage or verification, user preferences, or even unintentionally. An improved understanding of switching rationales allows search providers to(More)
Devising a complete and correct set of roles has been recognized as one of the most important and challenging tasks in implementing role-based access control. A key problem related to this is the notion of goodness/interestingness&#8212;when is a role good/interesting&quest; In this article, we define the <i>Role Mining Problem</i> (RMP) as the problem of(More)
Highlights ► We identify scheduling flexibility issues in time-triggered Shared-Clock designs. ► We also identify reliability issues in such designs due to their CANbus topology. ► We propose a novel CANstar topology and a novel Shared-Clock algorithm. ► Improvements in flexibility and reliability are shown through case studies.
Recently, it was observed that reverse-translocated cytosolic PrP and PrP expressed in the cytosol induce rapid death in neurons (Ma, J., Wollmann, R., and Lindquist, S. (2002) Science 298, 1781-1785). In this study, we investigated whether accumulation of prion protein (PrP) in the cytosol is toxic to human neurons in primary culture. We show that in these(More)
A key problem in information retrieval is inferring the searcher's interest in the results, which can be used for implicit feedback, query suggestion, and result ranking and summarization. One important indicator of searcher interest is gaze position - that is, the results or the terms in a result listing where a searcher concentrates her attention.(More)
To date, ¹¹C-(R)-PK11195 has been the most widely used TSPO PET imaging probe, although it suffers from high non-specific binding and low signal to noise. A significant number of 2nd generation TSPO radioligands have been developed with higher affinity and/or lower non-specific binding, however there is substantial inter-subject variation in their affinity(More)