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AIM To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). METHODS The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors,(More)
Generation of hepatocyte from embryonic stem cells (ESCs) holds great promise for hepatocyte replacement therapy to treat liver diseases. Achieving high efficiency of directed differentiation of ESCs to hepatocyte is of critical importance. Previously, Wnt3a has been reported to promote Activin A-induced human definitive endoderm (DE) differentiation, the(More)
SETDB1, a histone methyltransferase responsible for methylation of histone H3 lysine 9 (H3K9), is involved in maintenance of embryonic stem (ES) cells and early embryonic development of the mouse. However, how SETDB1 regulates gene expression during development is largely unknown. Here, we characterized genome-wide SETDB1 binding and H3K9 trimethylation(More)
Nowadays IMC-PID is widely used in industrial field, but time delay problem is an unavoidable problem existing in IMC-PID design. First order Pade approximation, second order symmetric Pade approximation and second asymmetric Pade approximation are usually adopted to approximate time delay item, but these three approximation methods may bring zero-points to(More)
Credit risk rating is used to judge the risk degree of different enterprises and provides some references for measuring the default rates of different enterprises. The sufficient sample number can guarantee the accuracy and rationality of credit rating. It is very difficult to find the ideal large samples in reality, especially in the banking. This study(More)
With the increase in the types of products, more and more companies intend to manage the warehouse relying on WMS. However, the price is much higher because of the complexity, expensiveness and operation difficulty of the WMS on the market. This paper develops a WMS for small businesses. Moreover, the software achieves the target of managing storage,(More)
A complex logistics (CL) is often consisted of a number of entities such as manufacturers, suppliers, wholesalers and retailers. Under periodic review policy, simulation has become an efficient tool to optimize the order-up-to level of each entity in a CL where the customer demand of retailers is fuzzy. However, the number of order-up-to level design or(More)
Matlab has big and powerful functions to scientific calculation. The Matlab applications that use the capabilities of the World Wide Web to send data to Matlab for computation and to display the results in a Web browser were studied by using Matlab Web Server. A real physical experiment data treatment system adopted Browser/Server networking technique based(More)